Investigating how age affects the bronchial response to respiratory viruses
Comparison of SARS-CoV-2, AdenoVIRus and Rhinovirus Infection of the Respiratory Epithelium in CHILdren vs. the eLDerly
This study looks at how age affects the way our lungs respond to respiratory viruses like COVID-19 and the common cold, to help understand why kids and older adults get sick differently.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | N/A to 17 Years |
| Sex | All |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 1 site (Bordeaux) |
| Trial ID | NCT06224062 on ClinicalTrials.gov |
What this trial studies
The VIRCHILLD project aims to explore how age-related changes in bronchial epithelium physiology influence the response and susceptibility to respiratory viruses like SARS-CoV-2, adenovirus, and rhinovirus. By analyzing data from both children and the elderly, the study seeks to understand why these populations experience different outcomes during viral infections. The research involves collecting bronchial samples from patients undergoing routine bronchoscopy, allowing for a detailed examination of the bronchial epithelium's characteristics across age groups. This could lead to insights into targeted treatments and preventive measures for respiratory infections.
Who should consider this trial
Good fit: Ideal candidates include children under 18 requiring bronchoscopy and adults over 18 needing thoracic surgery.
Not a fit: Patients who do not require bronchoscopy or thoracic surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of respiratory virus infections in different age groups, potentially reducing morbidity and mortality.
How similar studies have performed: While there is ongoing research into age-related responses to respiratory viruses, this specific approach focusing on bronchial epithelium physiology is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For pediatric patients requiring research-specific bronchial brushing: * Child under 18 years old, * Requiring bronchoscopy as part of routine care * Having informed and signed consent from the holders of parental authority For pediatric patients whose bronchial brushing will be carried out as part of their care and for those whose surgical waste will be collected for research: * Child under 18 years old, * Requiring as part of routine care bronchoscopy and brushing or bronchial fibroscopy under general anesthesia or surgical resection/lobectomy * Having expressed their non-opposition to their child's participation in research For adult patients: * Man or woman * Aged 18 or over * Requiring as part of the care, thoracic surgery such as lobectomy, pneumonectomy or lung transplantation in the Thoracic Surgery Department of Haut Lévêque du Chu Hospital in Bordeaux or inclusion in the TUBE study, described below. * having received an information note and not having objected to their participation in the research Exclusion Criteria: * No affiliation or non-beneficiary of a social security system * During a period of relative exclusion compared to another protocol * Patient born before 36 weeks of amenorrhea * Patient with a documented history of pulmonary fibrosis, primary pulmonary hypertension, cystic fibrosis, pulmonary malformation or chronic viral infections (hepatitis, HIV). * Patient with any dental, nasopharyngeal or bronchial infection with fever (\> 38°C) requiring systemic antibiotics in the previous 4 weeks
Where this trial is running
Bordeaux
- Bordeaux University Hospital — Bordeaux, France (Recruiting)
Study contacts
- Principal investigator: Michael FAYON, MDPhD — University Hospital, Bordeaux
- Study coordinator: Thomas TRIAN, PhD
- Email: thomas.trian@u-bordeaux.fr
- Phone: 05 55 47 30 27 50
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.