Investigating how age affects retinal oxygen extraction in healthy individuals
Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects
This study is testing how age affects the way healthy people's eyes use oxygen and looks at changes in eye blood flow and oxygen levels when breathing pure oxygen.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 1 site (Vienna, State of Vienna) |
| Trial ID | NCT06643403 on ClinicalTrials.gov |
What this trial studies
This study aims to measure retinal oxygen extraction across different age groups in healthy individuals to identify age-related changes. It will utilize dynamic vessel analyzer and laser speckle flowgraphy to assess retinal blood flow and oxygen saturation. Additionally, the study will examine short-term changes in retinal metabolism induced by inhaling pure oxygen. Participants will include men and women aged 18 to 80 with normal ophthalmic findings and medical history.
Who should consider this trial
Good fit: Ideal candidates are healthy men and women aged between 18 and 80 years with normal ophthalmic findings.
Not a fit: Patients with clinically relevant illnesses, recent drug or alcohol abuse, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of retinal health across different ages and inform future treatments for age-related ocular diseases.
How similar studies have performed: While there may be studies on retinal oxygen extraction, this specific investigation into age-related changes in healthy subjects is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women aged between 18 and 80 years * Signed informed consent * Normal ophthalmic findings, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study * Normal findings in the medical history, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study * Nonsmokers Exclusion Criteria: * Abuse of alcoholic beverages or drugs * Participation in a clinical trial in the 3 weeks preceding the study * Symptoms of a clinically relevant illness in the 3 weeks before the first study day * Blood donation during the previous 3 weeks * Pregnant or breast-feeding women
Where this trial is running
Vienna, State of Vienna
- Department of Clinical Pharmacology, Medical University of Vienna, Austria — Vienna, State of Vienna, Austria (Recruiting)
Study contacts
- Study coordinator: Doreen Schmidl-Schordje, MD
- Email: doreen.schmidl@meduniwien.ac.at
- Phone: +43 1 40400
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.