Investigating how age affects retinal oxygen extraction in healthy individuals
Official title: Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects
Run by Medical University of Vienna · NCT06643403 · Data updated 2026-11-12
This study is testing how age affects the way healthy people's eyes use oxygen and looks at changes in eye blood flow and oxygen levels when breathing pure oxygen.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 1 site (Vienna, State of Vienna) |
| Status | Recruiting |
| Started | September 30, 2024 |
| Main results expected | December 31, 2025 |
| Study ends | January 31, 2026 |
| Registry record updated | November 21, 2025 |
| Trial ID | NCT06643403 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy men and women aged between 18 and 80 years with normal ophthalmic findings.
✕Probably not a fit
Patients with clinically relevant illnesses, recent drug or alcohol abuse, or those who are pregnant or breastfeeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to measure retinal oxygen extraction across different age groups in healthy individuals to identify age-related changes. It will utilize dynamic vessel analyzer and laser speckle flowgraphy to assess retinal blood flow and oxygen saturation. Additionally, the study will examine short-term changes in retinal metabolism induced by inhaling pure oxygen. Participants will include men and women aged 18 to 80 with normal ophthalmic findings and medical history.
Why it matters
Potential benefit: If successful, this study could enhance understanding of retinal health across different ages and inform future treatments for age-related ocular diseases.
How similar studies have gone: While there may be studies on retinal oxygen extraction, this specific investigation into age-related changes in healthy subjects is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women aged between 18 and 80 years * Signed informed consent * Normal ophthalmic findings, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study * Normal findings in the medical history, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study * Nonsmokers Exclusion Criteria: * Abuse of alcoholic beverages or drugs * Participation in a clinical trial in the 3 weeks preceding the study * Symptoms of a clinically relevant illness in the 3 weeks before the first study day * Blood donation during the previous 3 weeks * Pregnant or breast-feeding women
Where it's running
-
Department of Clinical Pharmacology, Medical University of Vienna, Austria
Vienna, State of Vienna, Austria Recruiting
Study contacts
- Study coordinator: Doreen Schmidl-Schordje, MD
- Email: doreen.schmidl@meduniwien.ac.at
- Phone: +43 1 40400
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.