Investigating how adiposomes affect blood vessel function in obesity and diabetes
Role of Adiposomes in Diabetes-Associated Endothelial Dysfunction and Restorative Effects of Exercise and Metabolic Surgery
This study is testing how tiny particles from fat tissue affect blood vessel health in people with obesity and diabetes, while also seeing if exercise can help improve this issue.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | University of Illinois at Chicago Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Trial ID | NCT05199454 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the role of adiposomes, which are extracellular vesicles released from adipose tissue, in endothelial dysfunction associated with obesity and type II diabetes. The researchers will investigate how these adiposomes communicate unhealthy lipid profiles to endothelial cells, potentially contributing to cardiovascular disease. Participants will engage in a moderate-intensity exercise program to assess the impact of physical activity on the mechanisms of vascular dysfunction. The study focuses on understanding the molecular pathways involved in these conditions to develop corrective strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are obese individuals aged 18-50 with a BMI of 35 kg/m2 or higher and diagnosed with type II diabetes.
Not a fit: Patients with chronic heart, liver, or kidney diseases, autoimmune diseases, or cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new therapeutic strategies for improving vascular health in obese diabetic patients.
How similar studies have performed: While the specific role of adiposomes in endothelial dysfunction is a novel approach, related studies have shown that targeting vascular dysfunction in obesity and diabetes can lead to significant improvements.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI ≥ 35 kg/m2 * Between ages 18-50 years * Not pregnant * Diabetic (Current use of diabetes medication or fasting glucose ≥126 mg/dL) * Medical clearance to participate in a moderate-intensity exercise program Exclusion Criteria: * Pregnant women * Current smokers * Currently abusing alcohol or drugs * Chronic heart, liver, or kidney diseases, autoimmune diseases, or cancer * Non-English speakers * History of allergic reactions to lidocaine
Where this trial is running
Chicago, Illinois
- University of Illinois at Chicago — Chicago, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: Abeer M Mohamed, MD, PhD — University of Illinois at Chicago
- Study coordinator: Abeer M Mohamed, MD, PhD
- Email: amahmo4@uic.edu
- Phone: 312-355-8099
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.