Investigating how adiposomes affect blood vessel function in obesity and diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the role of adiposomes, which are extracellular vesicles released from adipose tissue, in endothelial dysfunction associated with obesity and type II diabetes. The researchers will investigate how these adiposomes communicate unhealthy lipid profiles to endothelial cells, potentially contributing to cardiovascular disease. Participants will engage in a moderate-intensity exercise program to assess the impact of physical activity on the mechanisms of vascular dysfunction. The study focuses on understanding the molecular pathways involved in these conditions to develop corrective strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* BMI ≥ 35 kg/m2
* Between ages 18-50 years
* Not pregnant
* Diabetic (Current use of diabetes medication or fasting glucose ≥126 mg/dL)
* Medical clearance to participate in a moderate-intensity exercise program

Exclusion Criteria:

* Pregnant women
* Current smokers
* Currently abusing alcohol or drugs
* Chronic heart, liver, or kidney diseases, autoimmune diseases, or cancer
* Non-English speakers
* History of allergic reactions to lidocaine

Where it's running

• University of Illinois at Chicago
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: Abeer M Mohamed, MD, PhD — University of Illinois Chicago
• Study coordinator: Abeer M Mohamed, MD, PhD
• Email: amahmo4@uic.edu
• Phone: 312-355-8099

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.