Investigating hormone therapy effects on heart and kidney health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between the method of estrogen administration (transdermal vs. oral) and the associated cardiorenal risks in both cisgender and transgender women. Additionally, it will assess the impact of exogenous testosterone on cardiorenal risks in cisgender and transgender men. Participants will undergo a series of tests, including blood draws and non-invasive monitoring, during a 4.5-hour lab session while fasting. The study seeks to provide insights into how hormone therapy affects cardiovascular and renal health across different gender identities.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 to 90 years
* Taking hormones orally or non-orally (either estrogen, progesterone or testosterone)

Exclusion Criteria:

* Cardiovascular disease (symptoms consistent with myocardial ischemia, previously documented myocardial ischemia, cardiac arrhythmias or valve abnormalities, or abnormal ECG at screening)
* Cerebrovascular disease (transient ischemic attacks or stroke)
* History of hypertension (BP\>140/90 or use of antihypertensive medications)
* Estimated glomerular filtration rate (eGFR) \< 60 ml/min/1.73m2
* Diabetes mellitus (defined by history, use of hypoglycaemic agents or a fasting glucose \>7mmol/L)
* Current smoker
* Previous history of preeclampsia
* Anabolic steroids, cortical steroids, or non-steroidal anti-inflammatory medications, or at the discretion of the investigator.

Where it's running

• University of Calgary
  Calgary, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Sofia Ahmed, MD — Alberta Health services
• Study coordinator: Darlene Y Sola, BScN
• Email: dsola@ucalgary.ca
• Phone: 4032107434

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.