Investigating heart transplant rejection and failure using imaging techniques
Morphological and Functional Changes After Heart Transplantation - Role of Noninvasive Imaging in the Early Detection of Cardiac Allograft Rejection and Vasculopathy
This study is testing different imaging methods to see how the heart changes after a transplant and to help doctors spot problems like rejection or blood vessel issues earlier.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Semmelweis University Heart and Vascular Center Academic / other |
| Locations | 1 site (Budapest) |
| Trial ID | NCT03499197 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the cardiovascular changes that occur after heart transplantation, focusing on differentiating between adaptive and pathological responses. It employs various imaging modalities, including cardiac magnetic resonance imaging, echocardiography, and invasive coronary imaging, alongside laboratory tests and patient questionnaires. The goal is to enhance early diagnosis of cardiac allograft rejection and vasculopathy through comprehensive cardiovascular assessments.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals who have undergone their first heart transplantation.
Not a fit: Patients experiencing cardiogenic shock after day 28 post-transplant or those unable to provide consent or cooperate will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and management of heart transplant rejection and failure, enhancing patient outcomes.
How similar studies have performed: Other studies utilizing advanced imaging techniques for cardiac allograft assessment have shown promising results, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * First heart transplantation Exclusion Criteria: * Cardiogenic shock on/after day 28 after heart transplantation * Lack of consent * Lack of cooperation
Where this trial is running
Budapest
- Heart and Vascular Center, Semmelweis University — Budapest, Hungary (Recruiting)
Study contacts
- Study coordinator: Hajnalka Vago, MD, PhD
- Email: vagoha@gmail.com
- Phone: +3620 8258058
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.