Investigating heart issues in patients with nonobstructive coronary arteries
Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3 - Pilot Study of Prevalence of Coronary Microvascular Dysfunction in Myocardial Infarction with Nonobstructive Coronary Arteries
This study is trying to see if adding adenosine during heart scans can help better diagnose heart problems in people who have had a heart attack but don’t have blocked arteries.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 85 (estimated) |
| Ages | 35 Years to 79 Years |
| Sex | All |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Trial ID | NCT05426408 on ClinicalTrials.gov |
What this trial studies
This pilot study aims to explore the prevalence of coronary microvascular dysfunction (CMD) in patients diagnosed with myocardial infarction with nonobstructive coronary arteries (MINOCA). It will assess whether the diagnostic accuracy can be enhanced by incorporating adenosine during cardiac magnetic resonance imaging (CMR). Patients will serve as their own controls, allowing for a more personalized evaluation of the intervention's effectiveness.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 35-80 with a suspected diagnosis of MINOCA or takotsubo syndrome and no significant coronary artery blockage.
Not a fit: Patients with claustrophobia, significant arrhythmias, or other severe cardiac conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods for patients experiencing heart issues despite having clear coronary arteries.
How similar studies have performed: While this approach is innovative, similar studies have not been widely reported, indicating that this may be a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiography without diameter stenosis ≥50% * age 35-80 years * reading and writing proficiency in Swedish Exclusion Criteria: * Claustrofobia * Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III) * Asthma or severe chronic obstructive lung disease * eGFR \< 30 ml/min * spontaneous coronary artery dissection * acute pulmonary embolism * acute myocardial infarction type 2 * cardiomyopathy other than takotsubo syndrome * a previous myocardial infarction due to CAD
Where this trial is running
Stockholm
- Per Tornvall — Stockholm, Sweden (Recruiting)
Study contacts
- Principal investigator: Per Tornvall, MD — Karolinska Instítutet
- Study coordinator: Per Tornvall, MD
- Email: per.tornvall@ki.se
- Phone: +468616100
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.