Investigating heart function changes during kidney treatment in critically ill patients
Is Myocardial Stunning Induced by Continuous Renal Replacement Therapy a Reality in Critically Ill Patients?
This study is testing how kidney treatment affects heart function in critically ill patients to see if heart issues are common during this therapy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 42 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 3 sites (Bron and 2 other locations) |
| Trial ID | NCT05209230 on ClinicalTrials.gov |
What this trial studies
This study examines the phenomenon of myocardial stunning, which may occur during continuous renal replacement therapy in critically ill patients with acute kidney injury. The researchers hypothesize that this condition is common and not solely dependent on variations in cardiac loading conditions, potentially leading to peripheral hypoperfusion. The study will involve a control group to better understand the relationship between renal replacement therapy and heart function. Participants will undergo echocardiography to assess heart function during treatment.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with acute kidney injury grade 3 requiring renal replacement therapy.
Not a fit: Patients requiring emergency renal replacement therapy or those with chronic hemodialysis will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the management of critically ill patients undergoing renal replacement therapy by identifying and mitigating cardiac complications.
How similar studies have performed: While myocardial stunning during chronic intermittent hemodialysis is well-documented, this specific investigation into continuous renal replacement therapy is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years old * Acute Kidney Injury grade 3 (KDIGO) * Indication for renal replacement therapy for the clinician in charge Exclusion Criteria: * Emergency indication to renal replacement therapy (pH\<7.15, Kaliemia \> 6mmol/L, refractory pulmonary oedema) * Poor echogenicity with speckle tracking analysis failure * Chronic hemodialysis * Extra corporeal membrane oxygenation, left ventricular assist device.
Where this trial is running
Bron and 2 other locations
- Département d'anesthésie-réanimation Hôpital cardiologique Louis Pradel Groupe Hospitalier Est — Bron, France (Not_yet_recruiting)
- Ruste Martin — Bron, France (Recruiting)
- Hopital Edourd Herriot — Lyon, France (Recruiting)
Study contacts
- Principal investigator: RUSTE Martin, MD, Msc — Hospices Civils de Lyon
- Study coordinator: RUSTE Martin, MD, Msc
- Email: martin.ruste@gmail.com
- Phone: +33472118956
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.