Investigating heart function changes after stimulation in scar areas using the NOGA system
Changes in Regional and Global Cardiac Contractility After Stimulation in Scar Zone with the NOGA System
NA · University Hospital, Toulouse · NCT04757168
This study is testing if stimulating scar areas in the heart can improve heart function in patients who have had a heart attack and need treatment for fast heartbeats.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 12 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | University Hospital, Toulouse (other) |
| Locations | 1 site (Toulouse, CHU de Toulouse) |
| Trial ID | NCT04757168 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to explore the relationship between electrical changes and mechanical contractility in cardiac scar areas following a myocardial infarction. Using the NOGA system, researchers will stimulate these scar zones to assess any resulting changes in cardiac contractility. The study focuses on patients who require ventricular tachycardia ablation due to ischemic heart disease and aims to provide insights into the effectiveness of this approach. By correlating electrical activity with mechanical function, the trial seeks to enhance understanding of post-infarction cardiac recovery.
Who should consider this trial
Good fit: Ideal candidates include patients with ischemic heart disease who are scheduled for ventricular tachycardia ablation.
Not a fit: Patients without ischemic heart disease or those contraindicated for ventricular tachycardia ablation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients with myocardial infarction and ventricular tachycardia.
How similar studies have performed: While this approach is novel, similar studies have shown promising results in understanding cardiac function post-myocardial infarction.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Patients who should undergo ventricular tachycardia (VT) ablation after a myocardial infarction according to current recommendations, namely: patients with ischemic heart disease (ICD) and with episodes of sustained ventricular tachycardia responsible for internal electric shocks by the implantable automatic defibrillator (ICD) (grade IB recommendation) OR * patients with an MIC and an ICD, presenting a first episode of sustained ventricular tachycardia (grade IIa, B recommendation) * Affiliated with a social protection scheme * Having signed an informed consent Exclusion Criteria: * Contraindication or non-indication for ventricular tachycardia ablation * Women who are pregnant or of childbearing age and without contraception, breastfeeding women * Patients without ischemic heart disease * Patients under guardianship, curatorship or legal protection.
Where this trial is running
Toulouse, CHU de Toulouse
- ROLLIN Anne — Toulouse, CHU de Toulouse, France (RECRUITING)
Study contacts
- Principal investigator: Anne ROLLIN, MD — University Hospital, Toulouse
- Study coordinator: Anne ROLLIN, MD
- Email: rollin.a@chu-toulouse.fr
- Phone: 5 61 32 24 29
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Myocardial Infarction, stimulation in cardiac scar area