Investigating heart disease in people with haemophilia
Official title: The CACHE Study: Coronary Artery Care in HaEmophilia
Run by Oxford University Hospitals NHS Trust · NCT06706206 · Data updated 2026-11-12
This study is trying to see how having haemophilia affects the risk of heart disease in men aged 45 and older by using advanced heart imaging techniques.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 45 Years to 120 Years |
| Sex | Men only |
| Enrollment | 80 (estimated) |
| Sponsor | Oxford University Hospitals NHS Trust Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Oxford, Oxfordshire) |
| Status | Recruiting |
| Started | February 25, 2025 |
| Main results expected | January 2027 |
| Study ends | January 2032 |
| Registry record updated | November 6, 2026 |
| Trial ID | NCT06706206 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are males aged 45 years or older with haemophilia A or B and Factor VIII/IX levels below 40%.
✕Probably not a fit
Patients who are unable to provide informed consent or have significant renal impairment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the relationship between haemophilia and cardiovascular disease using advanced imaging techniques. It focuses on understanding how haemophilia affects the risk of developing heart disease as patients age, particularly in light of improved treatments that have increased life expectancy. The study will involve male participants aged 45 and older with specific levels of Factor VIII or IX deficiency, and will utilize a state-of-the-art photon-counting detector cardiac CT scanner to generate detailed heart images. The findings could provide insights into the unique cardiovascular risks faced by individuals with haemophilia.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cardiovascular risks in patients with haemophilia.
How similar studies have gone: While there is limited research specifically on cardiovascular disease in haemophilia, the study's approach using advanced imaging is innovative and could provide new insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be willing and able to give informed consent for participation in the study. * Male, aged 45 years or above (no upper age limit). * Haemophilia A or B with Factor VIII/IX less than 40% (0.40 IU/ml). Exclusion Criteria: * Participants unable or unwilling to give informed consent. * Participants unable to understand the English language. * Participants unable or unwilling to attend for the necessary scans and investigations. * Patients with absolute contra-indications to CT imaging will be excluded from the study. This includes: * Any known contraindications to CT iodinated Contrast. * Significant renal impairment (eGFR \<30 ml/min). * Any other medical conditions which would influence the reliability of the study results determined by the investigators.
Where it's running
-
Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals NHS Foundation Trust
Oxford, Oxfordshire, United Kingdom Recruiting
Study contacts
- Study coordinator: Susie Shapiro
- Email: susie.shapiro@ouh.nhs.uk
- Phone: +44 (0)1865 225316
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.