Investigating genetic variants in psychiatric disorders
Familial and Functional Study of Genetic Variants Identified in People With Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder or Resistant Depression
This study is trying to understand how certain genes might affect mental health conditions like schizophrenia and depression by looking at DNA from people with these disorders and their families.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondation FondaMental Academic / other |
| Locations | 1 site (Créteil) |
| Trial ID | NCT05480826 on ClinicalTrials.gov |
What this trial studies
This study focuses on analyzing genetic variants found in individuals with psychiatric disorders such as schizophrenia, bipolar disorder, autism spectrum disorder, and resistant depression. It aims to investigate how these genetic variants are inherited within families and to explore their functional consequences in the cells of patients and their relatives. The study will enrich biocollections with DNA samples from blood or saliva, as well as hair follicles from participants, to facilitate further genetic analysis. Participants must be over 18 years old and affiliated with the social security system.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with a diagnosis of bipolar disorder, unipolar depression, schizophrenia, or autism spectrum disorder.
Not a fit: Patients who do not have a psychiatric disorder or those unable to understand French may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the genetic underpinnings of psychiatric disorders, potentially leading to improved diagnosis and treatment options.
How similar studies have performed: Other studies have shown promise in understanding genetic contributions to psychiatric disorders, making this approach both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * For patients: * Subjects suffering from (according to DSM IV criteria) : Bipolar disorder, Unipolar depression, Schizophrenia, Autism spectrum disorder * Age over 18 years * Subject affiliated to the social security system * Including patients under guardianship, curatorship, * Patients included in the Fondation FondaMental cohort whose genetic analyses have revealed the need for comparative and functional genetic studies. * Having signed the consent form For relatives : * Age over 18 years * Relative of patient included in the Fondattion FondaMental cohort * Including relative under guardianship, curatorship * Having signed the consent * Affiliated to social security Exclusion Criteria: * For all subjects: * Any condition that, in the opinion of the investigator, would make the subject's participation in the study undesirable or that would compromise compliance with the protocol * Persons deprived of liberty * Inability to understand French
Where this trial is running
Créteil
- Hopital Albert Chenevier — Créteil, France (Recruiting)
Study contacts
- Study coordinator: Stephane JAMAIN, PhD
- Email: stephane.jamain@inserm.fr
- Phone: 149813775
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.