Investigating genetic factors in diseases affecting premature infants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between genetic variations and the susceptibility to chronic lung disease (CLD) and other complications in very low birth weight (VLBW) infants. It focuses on understanding how specific gene variants, particularly those related to toll-like receptors, may influence the risk of developing conditions such as necrotizing enterocolitis, sepsis, and intraventricular hemorrhage. Additionally, the study will assess whether certain biomarkers in serum can help identify infants at higher risk for these diseases. By examining the interplay of genetic factors and biomarkers, the research seeks to provide insights into the pathogenesis of these serious conditions in premature infants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Infants born weighing less than 1500 grams

Exclusion Criteria:

* Infants born with congenital heart disease (other than patent ductus arteriosus)
* major congenital anomalies of the GI tract, respiratory tract, or kidneys

Where it's running

• Children's Wisconsin
  Milwaukee, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: G. Ganesh Konduri, MD — Medical College of Wisconsin
• Study coordinator: G. Ganesh Konduri, MD
• Email: gkonduri@mcw.edu
• Phone: 414.266.6820

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.