Investigating genetic factors in allergic rhinitis severity
Brain-derived Neurotrophic Factor (BDNF) Single Nucleotide Gene Polymorphism and Nerve Growth Factor as Risk Factors That Increase Severity of Allergic Rhinitis
This study is trying to see if certain genes affect how severe allergic rhinitis is for people who have it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 20 Years to 70 Years |
| Sex | All |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag) |
| Trial ID | NCT05907733 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between brain-derived neurotrophic factor (BDNF) gene polymorphisms and nerve growth factor levels as potential risk factors that may increase the severity of allergic rhinitis. By genotyping chronic allergic rhinitis patients, the study seeks to understand how genetic and immunological factors contribute to the condition. The findings could provide insights into the underlying mechanisms of allergic diseases and their impact on patient health.
Who should consider this trial
Good fit: Ideal candidates for this study are chronic allergic rhinitis patients who are currently on anti-allergic therapy.
Not a fit: Patients who are not on anti-allergic therapy or have other forms of allergic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of allergic rhinitis, potentially guiding personalized treatment strategies.
How similar studies have performed: While there is ongoing research into genetic factors in allergic diseases, this specific approach focusing on BDNF and nerve growth factor in allergic rhinitis is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The chronic AR patients on anti-allergic . Exclusion Criteria: * The chronic AR patients on anti-allergic therapy will be excluded.
Where this trial is running
Sohag
- Sohag university Hospital — Sohag, Egypt (Recruiting)
Study contacts
- Study coordinator: zeinab M Kadry, lecturer
- Email: zainbmahmoud@med.sohag.edu.eg
- Phone: 01225960747
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.