Investigating genetic factors in a rare lung cancer
Genetic Susceptibility Study of Primary Pulmonary Lymphoepithelioma-like Carcinoma
Sun Yat-sen University · NCT06801977
This study is trying to find out if certain genes are linked to a rare lung cancer that mostly affects people in Asia by comparing the genetic information of patients with the disease to healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sun Yat-sen University (other) |
| Locations | 2 sites (Foshan, Guangdong and 1 other locations) |
| Trial ID | NCT06801977 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on primary pulmonary lymphoepithelioma-like carcinoma (pLELC), a rare form of lung cancer that primarily affects the Asian population. It aims to uncover genetic susceptibility loci and pathogenic genes associated with the disease through a genome-wide association study. By comparing genetic data from patients diagnosed with pLELC to healthy controls, the study seeks to provide new insights into the genetic mechanisms underlying this cancer. The research utilizes advanced genotyping techniques to analyze the genetic profiles of participants.
Who should consider this trial
Good fit: Ideal candidates include individuals with a pathological diagnosis of primary pulmonary lymphoepithelioma-like carcinoma.
Not a fit: Patients diagnosed with metastatic nasopharyngeal carcinoma or those with severe cardiovascular, liver, or kidney diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of the genetic factors contributing to primary pulmonary lymphoepithelioma-like carcinoma, potentially guiding future prevention and treatment strategies.
How similar studies have performed: While this study is novel in its focus on the genetic aspects of pLELC, similar genetic studies in other cancers have shown promising results in identifying susceptibility genes.
Eligibility criteria
Show full inclusion / exclusion criteria
Case: Inclusion criteria: The subject is pathologically diagnosed with primary pulmonary lymphoepithelioma-like carcinoma. Exclusion criteria: The subject is diagnosed with metastatic nasopharyngeal carcinoma; The subject has heavy cardiovascular, liver, or kidney disease. Controls: Inclusion criteria: The subject is in good physical condition and has a stable level of consciousness; Exclusion criteria: The subject has prevalent cancer; The subject has heavy cardiovascular, liver, or kidney disease.
Where this trial is running
Foshan, Guangdong and 1 other locations
- Foshan First People's Hospital — Foshan, Guangdong, China (RECRUITING)
- Sun Yat-sen University Cancer Center — Guangzhou, Guangdong, China (RECRUITING)
Study contacts
- Study coordinator: Wei-Hua Jia, MD
- Email: jiawh@sysucc.org.cn
- Phone: 86+020-87342327
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Primary Pulmonary Lymphoepithelioma-like Carcinoma, Genome-Wide Association Study, primary Pulmonary Lymphoepithelioma-like Carcinoma