Investigating genetic factors affecting postoperative pain in children
COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children Undergoing Orthopedic, Abdominal, Thoracic, and Plastic Surgeries.
This study is trying to see if certain genes affect how much pain children aged 8 to 18 feel after surgery and how well pain medicine works for them.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 8 Years to 18 Years |
| Sex | All |
| Sponsor | American University of Beirut Medical Center Academic / other |
| Locations | 1 site (Beirut) |
| Trial ID | NCT06777875 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the impact of specific genetic variations, namely the A118G SNP in the OPRM1 gene and various SNPs in the COMT gene, on postoperative pain experiences in children aged 8 to 18 undergoing different types of surgeries. By assessing pain scores, sedation levels, and opioid requirements, the study seeks to understand how these genetic factors may influence pain management outcomes. A cohort of 200 children will be recruited, and their genetic profiles will be analyzed to determine correlations with pain perception and analgesic needs.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 8 to 18 who are scheduled for orthopedic, abdominal, thoracic, or plastic surgeries.
Not a fit: Patients with psychiatric disorders, severe pain conditions requiring surgical treatment, or those receiving regional anesthesia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized pain management strategies for children based on their genetic profiles.
How similar studies have performed: While the investigation of genetic factors in pain management is an emerging field, similar studies have shown promising results in understanding pain sensitivity and opioid response, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All children 8 years to 18 years * Undergoing orthopedic, abdominal, thoracic, and plastic surgeries * American Society of Anesthesiologists classification (ASA) I-II-III Exclusion Criteria: * Children with schizoid personality disorders, phobias, and anxiety * Patients with neuropathic pain associated with surgeries requiring surgical treatment. * Children presented with all types of depressive disorders, atypical bipolar disorder, or a suspicion of substance abuse. * American Society of Anesthesiologists classification (ASA) ≥IV * All patients receiving regional anesthesia, local blocks, epidural and caudal blocks.
Where this trial is running
Beirut
- Roland Kaddoum — Beirut, Lebanon (Recruiting)
Study contacts
- Principal investigator: Roland Kaddoum, MD — American University of Beirut Medical Center
- Study coordinator: Roland Kaddoum, MD
- Email: rk16@aub.edu.lb
- Phone: 01350000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.