Investigating genetic factors affecting postoperative pain in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the impact of specific genetic variations, namely the A118G SNP in the OPRM1 gene and various SNPs in the COMT gene, on postoperative pain experiences in children aged 8 to 18 undergoing different types of surgeries. By assessing pain scores, sedation levels, and opioid requirements, the study seeks to understand how these genetic factors may influence pain management outcomes. A cohort of 200 children will be recruited, and their genetic profiles will be analyzed to determine correlations with pain perception and analgesic needs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All children 8 years to 18 years
* Undergoing orthopedic, abdominal, thoracic, and plastic surgeries
* American Society of Anesthesiologists classification (ASA) I-II-III

Exclusion Criteria:

* Children with schizoid personality disorders, phobias, and anxiety
* Patients with neuropathic pain associated with surgeries requiring surgical treatment.
* Children presented with all types of depressive disorders, atypical bipolar disorder, or a suspicion of substance abuse.
* American Society of Anesthesiologists classification (ASA) ≥IV
* All patients receiving regional anesthesia, local blocks, epidural and caudal blocks.

Where it's running

• Roland Kaddoum
  Beirut, Lebanon Recruiting

Study contacts

• Principal investigator: Roland Kaddoum, MD — American University of Beirut Medical Center
• Study coordinator: Roland Kaddoum, MD
• Email: rk16@aub.edu.lb
• Phone: 01350000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.