Investigating genetic and microbiome factors in recurrent pregnancy losses
Evaluation of Predisposing Factors for Idiopathic Recurrent Pregnancy Losses: a Study Using a Genomic and Microbiota Approach
This study is trying to find out if certain genes and bacteria in the uterus are linked to women who have had multiple pregnancy losses.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Sex | Female |
| Sponsor | Hospital de Clinicas de Porto Alegre Academic / other |
| Locations | 1 site (Porto Alegre, Rio Grande do Sul) |
| Trial ID | NCT06604338 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the genetic and microbiome factors associated with recurrent pregnancy losses (RPL). It will analyze the exomes of women who have experienced RPL and compare them with population genomic databases to identify potential genetic predispositions. Additionally, the study will characterize the uterine microbiota of these women to understand its role in RPL. By combining genomic and microbiomic approaches, the study seeks to shed light on the unexplained cases of RPL.
Who should consider this trial
Good fit: Ideal candidates include women with a history of at least two spontaneous pregnancy losses without a determined cause.
Not a fit: Patients with fewer than two spontaneous pregnancy losses or those with a known cause for their pregnancy losses may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and potential interventions for women experiencing recurrent pregnancy losses.
How similar studies have performed: While there have been studies investigating genetic factors in RPL, the combination of genomic and microbiome analysis in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * RPL group: history of at least two spontaneous pregnancy losses, regardless of whether they have living children, and whose etiology for the pregnancy losses was not determined by the care team\'s protocols; * Control group: at least two full-term pregnancies and no history of difficulty getting pregnant, pregnancy loss or other infertility factors. Exclusion Criteria: * RPL group: less than two spontaneous pregnancy losses and those with a known cause for repeated pregnancy losses; * Control group: N/A
Where this trial is running
Porto Alegre, Rio Grande do Sul
- Hospital de Clínicas de Porto Alegre (HCPA) — Porto Alegre, Rio Grande do Sul, Brazil (Recruiting)
Study contacts
- Principal investigator: Lucas Rosa Fraga, PhD, Professor — Hospital de Clínicas de Porto Alegre
- Study coordinator: Lucas Rosa Fraga, PhD, Professor
- Email: lrfraga@hcpa.edu.br
- Phone: +555133597661
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.