Investigating gene expression in patients with atrial fibrillation after heart surgery
Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery (GENEXPRO Surg)
This study looks at the genes of patients who develop atrial fibrillation after heart surgery to see if certain genetic factors are involved.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 350 (estimated) |
| Ages | 20 Years to 99 Years |
| Sex | All |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT00833313 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the genetic factors that may contribute to the development of atrial fibrillation in patients following cardiac surgery. By analyzing atrial biopsies, researchers will compare the gene expression profiles of individuals who experience atrial fibrillation post-surgery with those who do not. The study seeks to identify specific regulatory events in atrial myocyte transcription and translation that may be influenced by genetic variations. Understanding these differences could provide insights into the mechanisms behind postoperative atrial fibrillation.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 20-99 who are scheduled to undergo cardiac surgery.
Not a fit: Patients who have had prior cardiac surgery, chest radiation, or recent chemotherapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to better predictive tools and targeted therapies for preventing atrial fibrillation in at-risk patients after heart surgery.
How similar studies have performed: While there have been studies on atrial fibrillation, this specific approach focusing on gene expression profiling in postoperative patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 20-99 years * Undergoing cardiac surgery Exclusion Criteria: * Prior cardiac surgery * chest radiation * recent chemotherapy
Where this trial is running
Boston, Massachusetts
- Brigham and Women's Hospital — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Jochen D Muehlschlegel, MD — Brigham and Women's Hospital
- Study coordinator: Jochen D Muehlschlegel, MD
- Email: jmuehlschlegel@partners.org
- Phone: 617-732-7330
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.