Investigating food aversion in anorexia nervosa patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study employs a meal-challenge protocol to evaluate how patients with anorexia nervosa metabolize food differently compared to healthy controls. It aims to understand the heritable and biochemical factors that influence food aversion and psychopathology in anorexia nervosa. By utilizing a multi-omics biomarker system, the research seeks to uncover the interactions between genetic predispositions and dietary factors, ultimately aiming to inform more effective treatment strategies for this serious disorder.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ill AN subjects will meet current Diagnostic and Statistical Manual of Mental Disorders (DSM V) diagnosis of AN, body mass index (BMI) between 11 kg/m² and 17.5 kg/m², or BMI \> 17.5 kg/m² with active eating disorder symptoms.
* Recovered AN must meet the following criteria at time of study entry: 1) Current or past DSM V diagnosis of AN; 2) BMI between 18.5 kg/m2 and 30 kg/m2; 3) Having maintained a BMI of \>18.5 for at least one year.
* Control must be healthy adolescent or woman negative on our screen for AN, other Axis I psychiatric illnesses, and having maintained a BMI of between 18.5-30 kg/m² since the age of 18.

Exclusion Criteria:

* Exclusion criteria for AN and control subjects include: Organic brain syndrome, schizophrenia and schizoaffective disorder, untreated thyroid disease, renal disease, hepatic disease, and the regular use of fish-oil containing supplements within the last three months of the study. All pregnant and lactating individuals will be excluded.

Where it's running

• UC San Diego Altman Clinical and Translational Research Institute
  La Jolla, California, United States Recruiting
• Program for Eating Disorders, Toronto General Hospital
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Pei-an (Betty) Shih, MPM, PhD — University of California, San Diego
• Study coordinator: Pei-an (Betty) Shih, MPM, PhD
• Email: eatingdisorderresearch@ucsd.edu
• Phone: (858) 534-0828

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Hormone and metabolic patterns in hypothalamus-like brain cells from people with anorexia nervosa

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• Narrative medicine workshops to support teens and young adults with anorexia nervosa (virtual)

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  Recruiting University of California, San Francisco · San Francisco, California · NCT07579442

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.