Investigating Flumazenil's Effects on Recovery from Anesthesia with Remimazolam

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the necessity of using flumazenil, a reversal agent, after administering remimazolam for total intravenous anesthesia in elderly patients undergoing hip joint surgery. It aims to evaluate the impact of flumazenil on recovery time and the occurrence of postoperative cognitive dysfunction. The research will consider factors such as age, obesity, and plasma albumin levels that may affect recovery. By comparing flumazenil with normal saline, the study seeks to clarify its role in clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients over 65 years old scheduled for hip joint surgery

Exclusion Criteria:

* Patients with impaired consciousness or delirium before surgery
* Patients who are hemodynamically unstable before surgery
* Patients with a history of neurological or neuromuscular disorders or use of medications that affect neurological or neuromuscular function
* Patients who have taken sedatives (anti-anxiety medications, antipsychotics, antidepressants, sleep aids) within the past 24 hours
* Patients with known allergy to benzodiazepine, flumazenil
* Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption
* Patients with hypersensitivity to Dextran40
* Patients who have been taking benzodiazepine for long term
* Patients with end stage renal disease requiring hemodialysis
* Patients with history of acute angle glaucoma
* Patients with alcohol or substance dependence
* ASA classification 4 or 5

Where it's running

• Pusan National University Yangsan Hospital
  Yangsan, Gyeongsangnam-do, South Korea Recruiting

Study contacts

• Study coordinator: Jaesang BAE, MD
• Email: wotkdqo@gmail.com
• Phone: 820553602129

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.