Investigating fluid responsiveness and venous congestion in critically ill patients during volume expansion
Dynamic Assessment of Fluid Responsiveness and Venous Congestion: Evolution of the VExUS Score During Volume Expansion
This study is testing how well critically ill patients respond to extra fluids and if they have too much fluid in their veins during treatment in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 64 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Bicetre Hospital Academic / other |
| Locations | 3 sites (Guangzhou, Guangdong and 2 other locations) |
| Trial ID | NCT06772038 on ClinicalTrials.gov |
What this trial studies
This observational study examines the relationship between fluid responsiveness and venous congestion in critically ill patients undergoing a standardized fluid challenge. It aims to understand how these two factors evolve over time following fluid administration, which is crucial for guiding fluid therapy in the ICU. By utilizing hemodynamic monitoring and pulse wave contour analysis, the study seeks to provide insights into the dynamics of fluid management in critically ill patients. The findings could enhance clinical decision-making regarding fluid therapy and improve patient outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are critically ill patients aged 18 years and older who are hospitalized in the ICU and undergoing hemodynamic monitoring.
Not a fit: Patients who are pregnant or those whose relatives refuse participation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved fluid management strategies, reducing the risk of fluid overload and enhancing recovery in critically ill patients.
How similar studies have performed: Previous studies have indicated a relationship between fluid responsiveness and venous congestion, but this study's approach of incorporating a fluid challenge is novel and aims to fill existing knowledge gaps.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Hospitalized in the intensive care unit (ICU) * Hemodynamic monitoring in place, with a pulse wave contour analysis- derived estimation of cardiac output (either calibrated or uncalibrated) * Decision made by clinicians to perform volume expansion through intravenous infusion of crystalloid fluid Exclusion Criteria: * Pregnancy * Refusal to participate by relatives of the patient or the patient himself
Where this trial is running
Guangzhou, Guangdong and 2 other locations
- First affiliated Hospital , Sun Yat-sen University — Guangzhou, Guangdong, China (Recruiting)
- Longgang Central Hospital of Shenzhen — Shenzhen, Guangdong, China (Recruiting)
- Bicetre Hospital — Paris, Val-de-Marne, France (Recruiting)
Study contacts
- Study coordinator: Xiang SI, MD
- Email: sixiang@mail.sysu.edu.cn
- Phone: 0626824692
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.