Investigating fetal cell receptors in postpartum women with skin ulcers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to analyze the transcriptomic profile of fetal cells in postpartum women, particularly focusing on the chemokine receptors that are overexpressed in these cells among women with various types of skin ulcers. Researchers will isolate fetal cells from the peripheral blood of both healthy postpartum women and those with skin ulcers, followed by RNA sequencing to identify differences. The study seeks to explore an alternative regenerative medicine strategy that utilizes fetal cells transferred during pregnancy, which may aid in wound healing. By understanding the role of these cells and their receptors, the study hopes to develop new therapeutic approaches for treating skin ulcers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Common criteria :

* Adult women,
* Post-partum: having been pregnant for any length of time,
* Having signed a free and informed consent form,
* Primiparous or multiparous,
* Affiliated to a health insurance

Patients :

\- Patients with a venous, diabetic or sickle cell ulcer, or mixed ulcer

Control group patients :

* Volunteers,
* Age-matched,
* Without skin ulcers.

There are no specific criteria for children.

Exclusion Criteria:

* Minors (for patients)
* Under court protection, curatorship, guardianship (for patients)
* Immunocompromised patients for any reason whatsoever
* Refusal of consent
* Refusal of blood and/or saliva samples for themselves or a member of their family

Where it's running

• Dermatology unit - Cochin Hospital - APHP
  Paris, Île-de-France Region, France Recruiting

Study contacts

• Study coordinator: Sélim ARACTINGI, MD, PHD
• Email: selim.aractingi@aphp.fr
• Phone: 00 33 1 58 41 18 13

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.