Investigating copeptin levels in children after neurosurgery for diabetes insipidus
Official title: A Study on the Trend of Serum Copeptin Levels and Its Clinical Value for Postoperative Central Diabetes Insipidus in Pediatric Patients After Neurosurgical Intervention in Intensive Care Unit
Run by Children's Hospital of Fudan University · NCT06742060 · Data updated 2026-11-12
This study looks at how copeptin levels change in children after brain surgery to see if it can help predict who will develop diabetes insipidus.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 29 Days to 18 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Children's Hospital of Fudan University Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | November 22, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | February 17, 2026 |
| Trial ID | NCT06742060 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include children aged 29 days to under 18 years who have undergone neurosurgical intervention.
✕Probably not a fit
Patients with pre-existing diabetes insipidus or structural diseases of the genitourinary system may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the trend of serum copeptin levels in pediatric patients following neurosurgical interventions. It focuses on comparing copeptin levels in children who develop transient or permanent central diabetes insipidus (CDI) against those who do not. Blood samples will be collected at various time points post-surgery to assess the relationship between copeptin levels and the occurrence of CDI. The study seeks to establish optimal detection times and cutoff values for copeptin in predicting postoperative CDI.
Why it matters
Potential benefit: If successful, this study could provide a reliable diagnostic tool for predicting central diabetes insipidus in pediatric patients after neurosurgery.
How similar studies have gone: While international studies have explored copeptin's clinical applications in adults, this specific approach in pediatric patients after neurosurgery is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female,age ≥29 days and \<18 years * After neurosurgical intervention * The patient agrees to comply with the requirements of the program, including follow-up visits and other related matters Exclusion Criteria: * Structural diseases of the genitourinary system (with the possibility of nephrogenic diabetes insipidus) * Preoperative symptoms of diabetes insipidus * Diabetes mellitus (HbA1c \>8.5%) * Drugs causing excessive drinking and urination (e.g., sodium-glucose cotransporter-2 inhibitors and diuretics) * Lack of follow-up data after 3 months
Where it's running
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Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Principal investigator: guoping Lu — Children's Hospital of Fudan University
- Study coordinator: gangfeng Yan
- Email: jinyi036@126.com
- Phone: +86 15900603082
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Serum endocan and copeptin levels in preterm babies with respiratory distress
This will test whether blood levels of endocan and copeptin on the first day of life are linked to how severe respiratory distress is in preterm newborns (28–36 weeks).
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.