Investigating color changes in chronic atrophic gastritis and early gastric cancer
Color Information From Linked Color Imaging is Associated With Mucosal Microvascular Density in Chronic Atrophic Gastritis and Early Gastric Cancer
This study is trying to see if changes in color in the stomach lining can help doctors understand chronic atrophic gastritis and early gastric cancer better in patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Affiliated Hospital to Academy of Military Medical Sciences Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT06152263 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between color changes and mucosal microvascular density in patients diagnosed with chronic atrophic gastritis (CAG) and early gastric cancer (EGC). Using linked color imaging (LCI), the study will capture images of the mucosa during esophagogastroduodenoscopy and quantify color values based on the International Commission on Illumination color space. Histopathological analysis will be performed on biopsy or resected specimens to evaluate microvascular density. The study will enroll 10 patients at the Fifth Medical Center of Chinese PLA General Hospital between September and December 2023.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with chronic atrophic gastritis or early gastric cancer confirmed by esophagogastroduodenoscopy.
Not a fit: Patients with severe anemia, portal hypertension, or those with inappropriate LCI images due to bleeding or ulceration may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the early detection and diagnosis of chronic atrophic gastritis and early gastric cancer through improved imaging techniques.
How similar studies have performed: While the approach of using linked color imaging is relatively novel, previous studies have indicated a correlation between color changes and gastrointestinal lesions, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed with chronic atrophic gastritis (CAG) and early gastric cancer (EGC). by esophagogastroduodenoscopy Exclusion Criteria: * Inappropriate LCI images as a result of bleeding, ulceration, or excessive mucosal congestion * Patients with severe anemia or portal hypertension * Patients diagnosed as having a mixture of the differentiated and undifferentiated types of gastric carcinoma, or having helicobacter pylori infection
Where this trial is running
Beijing, Beijing
- The Fifth Medical Center of Chinese PLA General Hosptial — Beijing, Beijing, China (Recruiting)
Study contacts
- Principal investigator: Yan Liu, MD — The Fifth Medical Center of Chinese PLA General Hosptial
- Study coordinator: Liang Wu, MD
- Email: wuliangdoc@163.com
- Phone: +8613911058553
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.