Investigating cognitive training and brain stimulation for long COVID symptoms
Brain Research and Integrative Neuroscience Network for COVID-19 (BRAINN)
This study is testing whether a combination of brain stimulation and cognitive training can help people with long COVID improve their thinking and overall quality of life.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 25 Years to 60 Years |
| Sex | Female |
| Sponsor | University of Cyprus Academic / other |
| Locations | 1 site (Nicosia, Cyprus) |
| Trial ID | NCT06517706 on ClinicalTrials.gov |
What this trial studies
This experimental study aims to evaluate the effectiveness of two interventions for managing cognitive symptoms associated with long COVID. Participants will be randomly assigned to either a group receiving active transcranial direct current stimulation (tDCS) combined with a Categorization Program (CP) or a control group receiving sham tDCS with the same CP. The study will involve neuroimaging and neuropsychological assessments to measure changes in cognition and quality of life before and after the interventions. Recruitment for this feasibility study is set to begin in June 2024, with a total of forty participants expected.
Who should consider this trial
Good fit: Ideal candidates are individuals experiencing cognitive difficulties as a result of COVID-19 infection.
Not a fit: Patients with significant neuropsychiatric or neurological conditions prior to contracting COVID-19 may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide new therapeutic options for patients suffering from cognitive impairments due to long COVID.
How similar studies have performed: While this approach is innovative, similar studies exploring cognitive interventions for long COVID have shown promise, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Reported cognitive difficulties due to COVID-19 infection * WHO Long COVID criteria will be used Exclusion Criteria: * Significant history of neuropsychiatric conditions prior to contracting COVID-19; history of neurological conditions such as TBI, CVA, MS prior to contracting COVID-19.
Where this trial is running
Nicosia, Cyprus
- University of Cyprus — Nicosia, Cyprus, Cyprus (Recruiting)
Study contacts
- Principal investigator: Fofi Constantinidou, Ph.D. — University of Cyprus
- Study coordinator: Fofi Constantinidou, Ph.D.
- Email: fofic@ucy.ac.cy
- Phone: +357 22892078
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.