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Investigating chronic pain after cardiac surgery

Determination of the Frequency and Affecting Factors of Chronic Postsurgical Pain After Cardiac Surgery: A Multicenter, Observational Study

Observational Ondokuz Mayıs University · NCT06382077

This study looks at how many people still have pain three months after their first heart surgery and what factors might affect their recovery.

Quick facts

Study typeObservational
Enrollment1176 (estimated)
Ages18 Years to 80 Years
SexAll
SponsorOndokuz Mayıs University Academic / other
Locations36 sites (Samsun, Atakum and 35 other locations)
Trial IDNCT06382077 on ClinicalTrials.gov

What this trial studies

The CPSP-Cardiac is a large, multi-center observational study aimed at understanding the incidence of chronic post-surgical pain in patients three months after cardiac surgery. It focuses on patients undergoing first-time cardiac surgeries, such as coronary artery bypass grafting and valvular repairs, and examines various factors that may influence pain outcomes. The study utilizes Enhanced Recovery After Surgery (ERAS®) protocols to improve pain management and patient recovery. By analyzing the effectiveness of multimodal analgesia strategies, including ultrasound-guided regional anesthesia, the study seeks to provide insights into preventing chronic pain and enhancing quality of life for cardiac surgery patients.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18-80 undergoing first-time cardiac surgery involving a median sternotomy.

Not a fit: Patients scheduled for minimally invasive cardiac surgery or those with severe organ dysfunction or psychiatric conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved pain management strategies that reduce the incidence of chronic pain in cardiac surgery patients.

How similar studies have performed: Other studies have shown promise in using multimodal analgesia and regional anesthesia techniques to improve acute pain management, but the long-term effects on chronic pain in this specific population remain less explored.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* patients will be undergoing a first-time cardiac surgery involving a median sternotomy, including coronary artery bypass grafting (CABG) and all open-heart procedures, such as valvular repairs/replacement.
* patients between the ages of 18-80 years
* American Society of Anesthesiologists (ASA) Physical Status score of II-III
* patients will also sign the written informed consent form

Exclusion Criteria:

* patients scheduled for minimally invasive cardiac surgery,
* patients with BMI\>40,
* patients who undergone thoracotomy,
* patients with alcohol and drug addiction,
* patients with severe dysfunction in a significant organ (e.g., presence of severe hepatic and renal disease),
* patients who undergone emergency and redo surgeries,
* patients who cannot be extubated within the first 8 hours postoperatively,
* patients have a severe psychiatric diseases such as psychosis or dementia that restrict cooperation with the patient (patients who cannot evaluate verbal numerical pain scales),
* patients who are pregnant and breastfeeding,
* patients who cannot be reached by phone during the postoperative follow-up periods
* patients who cannot communicate in the native language.

Where this trial is running

Samsun, Atakum and 35 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Chronic Post-surgical Paincardiac anesthesiachronic post-surgical painnerve blocks
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.