Investigating changes in the eye during retinal detachment
Study of Vitreoretinal Molecular Changes During Rhegmatogenous Retinal Detachment
This study is trying to see how the eye changes during retinal detachment by comparing samples from patients with this condition to those with other eye issues, to better understand what happens and improve treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 160 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 1 site (Dijon) |
| Trial ID | NCT06347302 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the molecular changes in the vitreous humor during rhegmatogenous retinal detachment, an urgent ophthalmological condition that can severely affect vision. By comparing samples from patients undergoing vitrectomy for retinal detachment with those undergoing surgery for other macular conditions, the researchers will analyze the presence of omega-3 PUFAs and proteins that may indicate inflammation and photoreceptor death. The findings could help clarify the underlying mechanisms of retinal detachment and improve patient outcomes. Blood, vitreous, sub-retinal fluid, and retinal tissue samples will be collected for analysis.
Who should consider this trial
Good fit: Ideal candidates include adults with primary retinal detachment requiring vitrectomy or those needing vitrectomy for macular surgery.
Not a fit: Patients with recurrent retinal detachment, pre-existing retinal pathology, or those who are pregnant or minors may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and treatment strategies for retinal detachment, potentially improving visual outcomes for patients.
How similar studies have performed: While previous studies have shown promising results in animal models, this research is novel as it seeks to confirm these findings in human subjects.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subject having given oral, free and informed consent to take part in the study * Subjects with primary retinal detachment requiring vitrectomy (RD group) Or * Subject requiring vitrectomy for macular surgery (primary epiretinal membrane or macular hole) (Control group) Exclusion Criteria: * Subject not affiliated to or not benefiting from national health insurance * Pregnant, parturient or breast-feeding women * Minors * Subject to a measure of legal protection (curatorship, guardianship) * Subjects of full age who are incapable or unable to express their consent * Subject who has already participated in the study * Subject with recurrent retinal detachment * Subjects with an epiretinal membrane of secondary origin (OVCR, inflammation, diabetic retinopathy) * Subject refusing blood sampling * Subjects with pre-existing retinal pathology (vascular or degenerative retinopathy) * People with diabetes
Where this trial is running
Dijon
- Chu Dijon Bourgogne — Dijon, France (Recruiting)
Study contacts
- Study coordinator: Petra EID
- Email: petra.eid@chu-dijon.fr
- Phone: 0380295173
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.