Investigating cell-free DNA in acute stroke patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the role of cell-free DNA (cfDNA) in patients experiencing acute ischemic stroke due to large vessel occlusion. Researchers will analyze cfDNA in the hyperacute phase of stroke using blood and thrombus samples to understand its relationship with stroke etiologies, procedural factors like secondary embolization, and reperfusion outcomes. The study will also investigate the correlation between cfDNA content in blood and thrombus and identify the specific sources of cfDNA in different stroke subtypes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Acute ischemic stroke due to large vessel occlusion (LVO) who require mechanical thrombectomy (detected in CT-Scan or MRI-Scan)
* 18 years of age

Exclusion Criteria:

* Patients currently undergoing immunological therapies.
* Patients with immunological diseases
* Patients with systemic infections at the time of admission

Where it's running

• University Hospital Basel
  Basel, Switzerland Recruiting

Study contacts

• Principal investigator: Gerrit Grosse, PD Dr. Dr. — University Hospital, Basel, Switzerland
• Study coordinator: Gerrit Grosse, PD Dr. Dr.
• Email: gerrit.grosse@usb.ch
• Phone: +41 61 32 85265

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Web-based therapy using action observation and mirror therapy for arm weakness after stroke

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• Remote Ischaemic Conditioning for Fatigue After Stroke 2

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  Recruiting Phase 2 Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT07914647

• Dual-task balance training plus computer-based cognitive training after stroke

  In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.

  Recruiting Matia Foundation · San Sebastián, GUIPUZCOA · NCT07913620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.