Investigating cell death mechanisms in lymphedema patients after surgery
The Role of Pyroptosis and Ferroptosis in the Pathophysiology of Lymphedema
This study is trying to see how surgery affects cell death in the fat tissue of people with lymphedema compared to those who haven't had the surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 20 Years to 100 Years |
| Sex | All |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Locations | 1 site (Kaohsiung) |
| Trial ID | NCT06237907 on ClinicalTrials.gov |
What this trial studies
This project examines the differences in cell death mechanisms, specifically apoptosis and iron-dependent cell death, in patients with lymphedema following surgical intervention. It focuses on the expression of these processes in subcutaneous adipose tissue and their roles in lymphatic endothelial cells, adipocytes, and macrophages. By comparing patients who have undergone lymphedema surgery with a control group, the study aims to uncover the pathophysiological mechanisms underlying lymphedema and the effects of surgical treatment on these processes.
Who should consider this trial
Good fit: Ideal candidates include patients with lymphedema who are undergoing lymphedema surgery and those requiring surgery for other conditions without lymphedema.
Not a fit: Patients with venous thrombosis, chronic heart failure, renal failure, or those who are pregnant or minors may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of lymphedema and lead to improved surgical outcomes and treatment strategies.
How similar studies have performed: While the specific focus on pyroptosis and ferroptosis in lymphedema is novel, similar studies have explored cell death mechanisms in other conditions with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Control Group: Patients who have not experienced lymphedema but require surgery due to other diseases such as cancer, trauma, chronic wounds, skin defects, etc. * Experimental Group: Patients who have lymphedema and undergone lymphedema surgery. Exclusion Criteria: * 1. Individuals with venous thrombosis, chronic heart failure, and renal failure. * 2. Vulnerable populations, individuals with limited mobility, pregnant women, and minors. * 3. Those expected to be unable to attend follow-up visits or complete the study smoothly. * 4. Participants who express doubts about the trial and cannot provide satisfactory answers.
Where this trial is running
Kaohsiung
- Kaohsiung Chang Gung Memorial Hospital — Kaohsiung, Taiwan (Recruiting)
Study contacts
- Study coordinator: Ching-Hua Hsieh, PhD
- Email: m93chinghua@gmail.com
- Phone: +886-7-7317123
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.