Investigating causes of unexplained iron deficiency anemia through endoscopy
Prevalence Of Significant Endoscopic and Histopathologic Findings in Patients Presenting With Unexplained Iron Deficiency Anemia: A Single Center Prospective Study
This study is testing to see if endoscopy can help find hidden causes of unexplained iron deficiency anemia in people who have this condition but don't know why.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 124 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah, Dakhlia) |
| Trial ID | NCT06430970 on ClinicalTrials.gov |
What this trial studies
This study aims to determine the prevalence of significant endoscopic and histopathologic findings in patients with unexplained iron deficiency anemia (IDA). A total of 124 patients with confirmed IDA, who have no obvious cause for their condition, will undergo upper and lower endoscopy to identify potential gastrointestinal issues. The study will also include tissue biopsies from any significant findings for further histopathological examination. Patients with certain exclusions, such as active bleeding or contraindications to sedation, will not be included in the study.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 70 with confirmed iron deficiency anemia and no obvious cause.
Not a fit: Patients with active bleeding, pregnant or lactating females, or those with contraindications to sedation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and treatment for patients suffering from unexplained iron deficiency anemia.
How similar studies have performed: Other studies have shown success in using endoscopic evaluations to identify causes of gastrointestinal diseases, supporting the potential effectiveness of this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Sex: both * Age: from 18 to 70 years * Cases confirmed iron deciency anemia with no obvious cause. * Significant UGI pathology includes Barrett's esophagus, esophagitis (LA class ≥ C), esophagogastric varices, peptic ulcer disease, duodenal ulcer, angioectasia , and cancer (Wuerth BA and Rockey DC,2018). * Significant LGI pathology includes adenomatous polyps \>1cm, angioectasias, rectal ulcer, IBS , colon polyps and cancer. ( Ghassemi KA and Jensen DM,2013). Exclusion Criteria: * Patients with active bleeding, pregnant or lactating female, contraindication of sedation (uncontrolled diabetes mellitus, uncontrolled thyroid disorders, pregnancy, respiratory embarrassment) were excluded.
Where this trial is running
Al Mansurah, Dakhlia
- Mansoura University — Al Mansurah, Dakhlia, Egypt (Recruiting)
Study contacts
- Study coordinator: Asmaa Gameel, MD
- Email: asmaagameel165@gmail.com
- Phone: 01025835429
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.