Investigating breathing and blood flow issues in young women with POTS
Mechanism of Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome in POTS Patients With Orthostatic Hyperpnea and Hypocapnia
This study is trying to understand how breathing and blood flow problems affect young women with POTS to see if it can help explain their symptoms like fast heart rate and brain fog.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 15 Years to 39 Years |
| Sex | Female |
| Sponsor | New York Medical College Academic / other |
| Locations | 1 site (Hawthorne, New York) |
| Trial ID | NCT05923840 on ClinicalTrials.gov |
What this trial studies
This study focuses on understanding the mechanisms behind Postural Orthostatic Tachycardia Syndrome (POTS) in young women, particularly those who experience hyperventilation. The researchers will compare the responses of female POTS patients aged 15 to 39 with and without orthostatic hyperpneic hypocapnia to healthy female volunteers. Using various interventions, including chemoreflex and baroreflex testing, the study aims to measure blood flow and respiratory responses during orthostatic stress tests. The goal is to identify how these physiological changes contribute to symptoms like tachycardia and brain fog in POTS patients.
Who should consider this trial
Good fit: Ideal candidates for this study are young females aged 15-39 diagnosed with Postural Orthostatic Tachycardia Syndrome.
Not a fit: Patients with systemic diseases or those unable to stop prescribed medications prior to the study may not benefit from this research.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and management of POTS, improving the quality of life for affected patients.
How similar studies have performed: While the specific approach of this study is novel, similar studies have shown promise in understanding POTS and its mechanisms.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The investigators will recruit female POTS cases (N=80) and healthy female control subjects (N=40) aged 15-39 years, matched for BMI. POTS is a disease in which 80-90% are females. Therefore, the investigators will only recruit female POTS patients and controls. Exclusion Criteria: * Any subjects with systemic disease or who cannot stop taking prescribed medications for at least 2 weeks prior to study.
Where this trial is running
Hawthorne, New York
- NewYork Medical College — Hawthorne, New York, United States (Recruiting)
Study contacts
- Principal investigator: Marvin S Medow, Ph.D. — New York Medical College
- Study coordinator: Marvin S Medow, Ph.D.
- Email: marvin_medow@nymc.edu
- Phone: 914-594-2848
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.