Investigating brain waste clearance and its link to postoperative delirium in elderly patients
Investigating the Link Between Preoperative Glymphatic Transport and Postoperative Delirium
Technical University of Munich · NCT06236854
This study is trying to see if problems with brain waste removal are linked to the risk of confusion after surgery in older patients aged 65 and up.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Technical University of Munich (other) |
| Locations | 1 site (München, Bayern) |
| Trial ID | NCT06236854 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between glymphatic transport impairment and the risk of postoperative delirium (POD) in elderly patients aged 65 and older. By measuring glymphatic transport, the study seeks to identify preoperative factors that may predispose certain patients to develop POD following surgery. The research focuses on understanding how perioperative stressors may exacerbate existing vulnerabilities in the glymphatic system, potentially leading to cognitive decline and other complications. The findings could help in developing strategies to mitigate the risk of POD in susceptible patients.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly patients aged 65 and older who are fluent in German and have at least one risk factor for postoperative delirium.
Not a fit: Patients who are scheduled for neurological surgery or have pre-existing neurological impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved identification and management of patients at risk for postoperative delirium, enhancing recovery and reducing healthcare costs.
How similar studies have performed: While the specific approach of measuring glymphatic transport in relation to POD is novel, there is existing literature on the risk factors for POD that supports the relevance of this investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>= 65 years of age * Fluent in German * Presence of at least one further risk factor for POD Exclusion Criteria: * Individuals who do not meet all inclusion criteria * Scheduled for neurological surgery * Pre-existing neurological structural impairments or previous brain surgery * ASA status 4 * Contraindication to MRI (e.g., pacemakers, artificial heart valves, cardioseal, aneurysm clips, implanted magnetic metal parts (screws, plates from surgery), cochlear implants, metal splitters/grenade splinters, acupuncture needle, insulin pump, piercings that cannot be removed, etc) * Scheduled for emergency procedures * Subjects with fear of confined spaces
Where this trial is running
München, Bayern
- Klinikum rechts der Isar der Technischen Universität München — München, Bayern, Germany (RECRUITING)
Study contacts
- Study coordinator: Rachel Nuttall, PhD
- Email: rachel.nuttall@tum.de
- Phone: 0894140
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Post-operative Delirium