Investigating brain stimulation effects on memory in older adults
Official title: Multimodal Investigation of Neural Plasticity Induced by Non-invasive Brain Stimulation
Run by University of Michigan · NCT06453980 · Data updated 2026-11-12
This study is testing if a type of brain stimulation can improve memory and brain function in older adults, especially those with mild cognitive impairment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | University of Michigan Academic / other |
| Locations | 1 site (Ann Arbor, Michigan) |
| Status | Recruiting |
| Started | May 13, 2024 |
| Main results expected | April 30, 2026 |
| Study ends | April 30, 2026 |
| Registry record updated | March 10, 2026 |
| Trial ID | NCT06453980 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include right-handed older adults with normal cognition or a diagnosis of mild cognitive impairment.
✕Probably not a fit
Patients with significant mental illness, other neurological conditions, or sensory impairments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the impact of high-definition transcranial direct current stimulation (HD-tDCS) on brain functioning and memory in older adults, including those with mild cognitive impairment (MCI). It aims to understand how this non-invasive brain stimulation affects brain activity and metabolism, particularly focusing on the neurotransmitter glutamate. Various brain imaging techniques, such as functional magnetic resonance spectroscopy (fMRS), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS), will be employed alongside cognitive tests to assess changes in brain response during memory tasks. The ultimate goal is to gather insights that could lead to new treatments for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this study could lead to new therapeutic approaches for improving memory and cognitive function in patients with mild cognitive impairment and potentially Alzheimer's disease.
How similar studies have gone: Other studies using non-invasive brain stimulation techniques have shown promise in improving cognitive functions, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Normal cognition for HC and diagnosis of Mild Cognitive Impairment (MCI) for MCI participants * Right-handedness * Magnetic resonance compatible, criteria that also apply for high definition transcranial direct current stimulation (HD-tDCS; e.g., absence of metallic or electronic implants in the upper body or head) Exclusion Criteria: * History of other contributing neurological or medical conditions known to affect cognitive functioning * Significant mental illness * Sensory impairments that limit ability to participate * History of alcohol or drug abuse/dependence
Where it's running
-
University of Michigan
Ann Arbor, Michigan, United States Recruiting
Study contacts
- Principal investigator: Alexandru Iordan, PhD — University of Michigan
- Study coordinator: Harini Babu, MSc
- Email: hariniba@umich.edu
- Phone: 734-647-3704
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.