Investigating brain function in epilepsy patients using implanted electrodes
Official title: Human Intracranial Electrophysiology
Run by Dartmouth-Hitchcock Medical Center · NCT05529264 · Data updated 2026-11-12
This study is testing how well different parts of the brain work in people with epilepsy who are getting ready for surgery, by using implanted electrodes to record brain activity while they do memory and attention tasks.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 175 (estimated) |
| Sponsor | Dartmouth-Hitchcock Medical Center Academic / other |
| Locations | 1 site (Lebanon, New Hampshire) |
| Status | Recruiting |
| Started | January 17, 2023 |
| Main results expected | August 1, 2027 |
| Study ends | August 1, 2032 |
| Registry record updated | January 15, 2026 |
| Trial ID | NCT05529264 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with a diagnosis of refractory epilepsy undergoing intracranial EEG recording.
✕Probably not a fit
Patients with additional neurological or psychiatric conditions that may interfere with the study are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study enrolls patients with epilepsy who are undergoing evaluation for surgery and have electrodes implanted in their brains or on their scalps. Participants will engage in daily sessions that test various cognitive functions such as memory, language, and attention while their brain activity is recorded using Human Intracranial Electrophysiology (HIE). The study aims to understand the localization and function of the human brain by analyzing brain signals during specific tasks, alongside other physiological data. This research builds on previous studies conducted at Dartmouth-Hitchcock Medical Center.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of brain function and improve treatment strategies for epilepsy.
How similar studies have gone: Previous studies using similar electrophysiological methods have shown promise in understanding brain function, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Patients with Intracranial EEG: Inclusion Criteria * Patients must be age 18 years or older. There is no upper age limit. * Patients must have a diagnosis of refractory epilepsy undergoing intracranial EEG recording for clinical purposes. Patients with Intracranial EEG: Exclusion Criteria * Patient has additional neurological condition (such as stroke or dementia) or a psychiatric condition (such as active psychosis or suicidal ideation) and are deemed inappropriate for the study * Patients are not able to provide informed consent for any reason (e.g. encephalopathic, experiencing a seizure) Patients with Scalp EEG: Inclusion Criteria * Patients must be age 18 years or older. There is no upper age limit. * Patients must have a probable diagnosis of epilepsy. Patients with Scalp EEG: Exclusion Criteria * Patient has additional neurological condition (such as stroke or dementia) or a psychiatric condition (such as active psychosis or suicidal ideation) and are deemed inappropriate for the study * Patients are not able to provide informed consent for any reason (e.g. encephalopathic, experiencing a seizure) Normal Controls: Inclusion Criteria * Participants must be age 18 years or older. There is no upper age limit. * Participants must be able to provide informed consent for themselves. Normal Controls: Exclusion Criteria • Determined not to be appropriate normal control for the study population
Where it's running
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Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States Recruiting
Study contacts
- Principal investigator: Krzysztof A Bujarski, MD — Dartmouth-Hitchcock Medical Center
- Study coordinator: Krzysztof A Bujarski, MD
- Email: krzysztof.a.bujarski@hitchcock.org
- Phone: 603-650-5104
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.