Investigating brain function differences in obesity subtypes
Research on Brain Function of Metabolism-based Artificial Intelligence Assisted Clinical Classification of Obesity
Shanghai 10th People's Hospital · NCT05892224
This study looks at how brain function differs among people with different types of obesity to see how it affects their health after weight loss surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Shanghai 10th People's Hospital (other) |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT05892224 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the brain function characteristics of patients with four different subtypes of obesity and how these relate to metabolic changes following laparoscopic sleeve gastrectomy (LSG). A total of 120 patients with obesity and 30 healthy individuals will undergo functional magnetic resonance imaging (fMRI) assessments at baseline and at multiple time points post-surgery. The study will evaluate various metabolic indicators and complications associated with weight loss to better understand the relationship between brain function and obesity-related health outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 16-65 with a BMI over 37.5 kg/m² or over 32.5 kg/m² with diabetes.
Not a fit: Patients with secondary causes of obesity, severe organ dysfunction, or contraindications for laparoscopic surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding of obesity subtypes and tailored interventions for better metabolic health outcomes.
How similar studies have performed: While there have been studies on obesity and brain function, this specific approach focusing on subtypes and their metabolic implications is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age ranged from 16-65 years old * BMI over 37.5kg/m2, or BMI over 32.5kg/m2 with diabetes which meets the recommended cut-off bariatric surgery of the Guidelines for surgical treatment of obesity accompanied with or without type 2 diabetes in China. Exclusion Criteria: * secondary causes of obesity such as hypothalamic obesity, Cushing syndrome, hypophysis dysfunction, etc * pregnancy or location * contraindications for laparoscopic surgery, such as gastrointestinal diseases of intra-abdominal infection, adhesion, etc * severe heart, liver, and kidney dysfunction * organic and systemic diseases intolerant of surgery.
Where this trial is running
Shanghai, Shanghai
- Shanghai Tenth People's Hospital — Shanghai, Shanghai, China (RECRUITING)
Study contacts
- Study coordinator: Shen Qu, Dr.
- Email: qushencn@hotmail.com
- Phone: (86)021-66301004
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obesity, Functional Neuroimaging, obesity, Brain, artificial intelligence