Investigating brain blood flow and elasticity in newborns using ultrasound techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess brain perfusion and tissue elasticity in neonates adapting to life outside the womb, particularly those with conditions like hypoxic ischemic encephalopathy and stroke. Utilizing contrast-enhanced ultrasound with sulphur hexafluoride and ultrasound-assisted elastography, the research will provide insights into cerebral hemodynamics. The study will recruit a total of 100 infants from the Neonatal Units of Turku University Hospital over a potential seven-year period. The ultrasound examinations will be performed without radiation or sedation, making it a safe approach for this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Babies less than 7 months treated at the neonatal units of Turku University hospital

Exclusion Criteria:

* Pre-known genetic disease
* Difficult congenital malformations that need surgical treatment
* Central nervous system tumors
* Weight less than 2,5 kg during examination
* Medical history of SonoVue hypersensitivity
* Uncontrolled systemic hypertension
* Systolic pulmonary artery pressure \> 90 mmHg
* Unstable cardiovascular state

Where it's running

• Turku University Hospital
  Turku, Southwestern Finland, Finland Recruiting

Study contacts

• Principal investigator: Tiina Laurikainen — Turku University Hospital
• Study coordinator: Tiina Laurikainen
• Email: tiina.laurikainen@tyks.fi
• Phone: +35823135941

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.