Investigating brain and eye markers of cognitive aging in older adults
Cerebral MRI Markers and Oculomotor Indices in Human Ageing: Potential Predictors of Cognitive Maintenance or Decline
NA · University Hospital, Toulouse · NCT06058897
This study tests how changes in a part of the brain and eye movements can help us understand cognitive aging in healthy older adults aged 60 and up.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 60 Years to 100 Years |
| Sex | All |
| Sponsor | University Hospital, Toulouse (other) |
| Locations | 1 site (Toulouse) |
| Trial ID | NCT06058897 on ClinicalTrials.gov |
What this trial studies
This research examines physiological and cognitive markers related to the locus coeruleus (LC) in cognitively-healthy individuals aged 60 and older. The study utilizes MRI and eye-tracking techniques to assess the integrity and function of the LC, which is crucial for noradrenaline production and cognitive functions such as attention and memory. Over an 18-month period, participants will undergo four visits, including detailed cognitive exams and imaging assessments, to explore the relationship between LC biomarkers and cognitive status.
Who should consider this trial
Good fit: Ideal candidates are cognitively-healthy adults over 60 years old who are part of the INSPIRE cohort.
Not a fit: Patients with neurological or psychiatric conditions, or those with contraindications to MRI, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to early identification of cognitive decline in aging individuals, allowing for timely interventions.
How similar studies have performed: While the specific combination of MRI and eye-tracking in this context is novel, similar studies have shown promise in understanding cognitive aging.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * INSPIRE cohort participant * Mini-Mental State Examination score ≥ 27 on 30 * Access to a web connection from participant's or relative's home and regular use of web surfing * Signature of the informed consent * Affiliated to a social security scheme Exclusion Criteria: * Any contra-indications to MRI exam * Ophthalmic pathology impacting eye-tracking measures * Neurological or psychiatric pathology * Person under guardianship or curatorship Contraindications to MRI examination: * Pacemaker or cardiac defibrillator * Implanted material activated by an electrical, magnetic or mechanical system * Haemostatic clips for intracerebral aneurysms or carotid arteries * Orthopedic implants * Claustrophobia Ophthalmological pathologies impacting eye tracking measurements: * Glaucoma * Age-related macular degeneration * Unoperated cataract
Where this trial is running
Toulouse
- University Hospital — Toulouse, France (RECRUITING)
Study contacts
- Principal investigator: Pierre PAYOUX, MD — University Hospital, Toulouse
- Study coordinator: Pierre PAYOUX, MD
- Email: payoux.p@chu-toulouse.fr
- Phone: 0562746169
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aging, ageing, locus coeruleus, noradrenaline, cognition, memory, MRI, pupillometry