Investigating brain activity patterns in movement disorders
Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement
This study is testing how brain activity changes during movement in people with Parkinson's disease and epilepsy to see if it helps us understand their conditions better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 1 site (Bordeaux) |
| Trial ID | NCT06241924 on ClinicalTrials.gov |
What this trial studies
This research aims to explore the oscillatory activity in the cortico-subcortical network during normal and pathological movements in patients with Parkinson's disease and drug-resistant epilepsy. By utilizing high-resolution electroencephalogram (EEG) and stereo-electro-encephalography (SEEG), the study will collect local field potentials while participants perform a simple motor task. The goal is to understand the relationship between the characteristics of these oscillations and movement patterns, which could provide insights into the underlying mechanisms of these disorders.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 to 75 with Parkinson's disease who have undergone electrode implantation or individuals with drug-resistant epilepsy undergoing pre-surgical assessment.
Not a fit: Patients who are unable to provide informed consent or have serious psychiatric or somatic illnesses may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of movement disorders and lead to improved treatment strategies for patients with Parkinson's disease and epilepsy.
How similar studies have performed: Other studies have shown promise in understanding brain oscillations in movement disorders, but this specific approach using high-resolution techniques is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria : * Male or Female * Between 18 and 75 years of age * With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device. * Giving free, informed, written consent signed by the participant and the investigator Or * With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG * With at least one electrode exploring the basal ganglia or the thalamus. * Able to perform the simple motor task * Affiliated or beneficiary of a social security scheme; * Giving free, informed, written consent signed by the participant and the investigator Exclusion criteria: * Be incapable of giving consent personally * Be subject to a legal protection measure or be placed under judicial protection; * Being pregnant or breastfeeding * Present a serious and/or decompensated somatic or psychiatric illness
Where this trial is running
Bordeaux
- CHU de Bordeaux — Bordeaux, France (Recruiting)
Study contacts
- Principal investigator: Jérôme AUPY, Docteur — University Hospital, Bordeaux
- Study coordinator: Jérôme AUPY, Docteur
- Email: jerome.aupy@u-bordeaux.fr
- Phone: 05 56 71 43 33
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.