Investigating brain activity in patients with PRRT2-related dyskinesia
Official title: Corrélats Neuronaux Des Accès de Mouvements Anormaux Paroxystiques Liées Aux Dyskinésies Paroxystiques kinésigéniques Secondaires à Une Mutation du Gene PRRT2 - Recherche Ancillaire de L'étude AMEDYST " Dont Vous êtes l'Investigateur Principal
Run by Institut National de la Santé Et de la Recherche Médicale, France · NCT06701851 · Data updated 2026-11-12
This study is trying to see how brain activity changes during episodes of abnormal movements in people with a PRRT2 mutation to better understand what happens in their brains.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 1 (estimated) |
| Sponsor | Institut National de la Santé Et de la Recherche Médicale, France Government |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | January 21, 2025 |
| Main results expected | January 2028 |
| Study ends | October 2029 |
| Registry record updated | June 5, 2026 |
| Trial ID | NCT06701851 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 18 to 75 with a PRRT2 mutation who can control their paroxysmal dyskinesia episodes.
✕Probably not a fit
Patients who are unable to comply with the study protocol or do not reside in France may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the neuronal correlates of paroxysmal dyskinesia episodes in patients with a PRRT2 mutation using functional MRI and EEG. It focuses on understanding the interactions between the striatum and cerebellum during these episodes, particularly during the prodromal phase and the refractory period. By analyzing brain activation and connectivity, the study seeks to uncover the mechanisms behind the control of abnormal movements and the perception of action control in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of paroxysmal dyskinesia, potentially enhancing treatment options for patients.
How similar studies have gone: While the specific approach of this study is novel, similar studies using functional imaging techniques have shown promise in understanding movement disorders.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Male or female Individuals with dystonic disease carrying a PRRT2 mutation and demonstrating the ability to control paroxysmal dyskinesia episodes. Affiliated with a health insurance system or a beneficiary of such a system. Individuals aged 18 to 75 years. Signature of informed consent Exclusion Criteria: Individuals under guardianship. Individuals not residing in France. Individuals unable to comply with protocol constraints (compliance with visit schedules and ability to perform required tasks). Individuals undergoing an exclusion period for another research study. Contraindications to MRI
Where it's running
-
Institut du Cerveau de la Moelle Epinière ICM, Hôpital Pitié Salpêtrière,
Paris, France Recruiting
Study contacts
- Study coordinator: Emmanuel Roze, MD, PhD
- Email: emmanuel.flamand-roze@psl.aphp.fr
- Phone: +33142162748
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.