Investigating brain activity in Parkinson's disease patients
Local Fields Potentials of the Subthalamic Nucleus in Patients With Parkinson's Disease and Neuropsychiatric Fluctuations
This study is trying to see how brain activity in people with Parkinson's disease relates to their movement and mood changes after they have had surgery to stimulate a specific part of the brain.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 12 (estimated) |
| Ages | 30 Years to 75 Years |
| Sex | All |
| Sponsor | University Hospital, Grenoble Academic / other |
| Locations | 1 site (Grenoble) |
| Trial ID | NCT05820425 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on understanding the electrophysiological activity of the subthalamic nucleus in patients with Parkinson's disease, particularly in relation to neuropsychiatric fluctuations. It aims to record local field potentials (LFP) and EEG to explore how these brain activities correlate with both motor and non-motor symptoms of the disease. The study will involve patients who have recently undergone bilateral subthalamic nucleus stimulation surgery and will assess their ability to complete questionnaires during different states of their condition. By analyzing these patterns, the research seeks to shed light on the underlying mechanisms of neuropsychiatric symptoms in Parkinson's disease.
Who should consider this trial
Good fit: Ideal candidates are adults aged 30 to 75 with a diagnosis of Parkinson's disease who experience fluctuations and have undergone recent bilateral subthalamic nucleus stimulation.
Not a fit: Patients with active psychosis, severe cognitive impairment, or those unable to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of neuropsychiatric symptoms in Parkinson's disease, enhancing patient quality of life.
How similar studies have performed: While there have been studies on the electrophysiological activity related to motor symptoms in Parkinson's disease, this specific focus on neuropsychiatric fluctuations is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 30 and 75 years * Diagnosis of Parkinson's disease with fluctuations and/or dyskinesias * Ability to collaborate and fill a questionnaire in the OFF state condition (this criterion will be assessed based on the results of the preoperative screening to retain indication for STN stimulation, which takes place whenever a PD patient has to undergo DBS surgery) * Surgery for bilateral STN stimulation with a Percept® (Medtronic) in the last 10 days * Absence of dementia (defined as MoCA score \> 24) Exclusion Criteria: * Active psychosis * Patients unable to provide an informed consent or under gardianship * Patients under judicial supervision or deprived of liberty * Pregnancy and breastfeeding
Where this trial is running
Grenoble
- CHU Grenoble Alpes — Grenoble, France (Recruiting)
Study contacts
- Principal investigator: Anna Castrioto, MD, PhD — CHU Grenoble Alpes
- Study coordinator: Pierre Pelissier, MsC
- Email: ppelissier@chu-grenoble.fr
- Phone: 4 76 76 94 59
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.