Investigating brain activity during rehabilitation exercises for multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to explore cortical activity during task-oriented exercises in individuals with multiple sclerosis and healthy volunteers using advanced imaging techniques. By observing brain activity in real-time during rehabilitation sessions, the study seeks to enhance understanding of the neural mechanisms that contribute to functional improvements. It will involve 40 healthy subjects and 20 individuals with multiple sclerosis, focusing on how rehabilitation impacts mobility and brain plasticity. The findings could provide insights into optimizing rehabilitation strategies for better patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* subjects between 18 and 60 years of age,
* diagnosis of MS (McDonald criteria, Thompson et al, 2018), stable disease course without worsening more than 1 EDSS point over the last 3 months, EDSS between 3 and 4.5 points,
* healthy right-handed volunteers,
* able to release a written informed consent.

Exclusion Criteria:

* Unable to comprehend the aims of the study and to follow test instructions;
* Diagnosis of major depression (DSM-5);
* Severe joint and/or bone disorders interfering with balance and gait (based upon clinical judgment);
* Cardiovascular diseases;
* Severe visual impairments interfering with the execution of the protocol;
* epilepsy;
* intake of neuroleptic and antiepileptic drugs.

Where it's running

• Università di Genova
  Genova, Italy Recruiting
• IRCCS Santa Maria Nascente - Fondazione Don Carlo Gnocchi
  Milan, Italy Recruiting
• Università degli Studi di Milano
  Milan, Italy Active not recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.