Investigating blood volume changes in patients undergoing hip replacement surgery
Official title: Perioperative Change in Blood Volume and Fluid Distribution in Total Hip Arthroplasty
Run by Copenhagen University Hospital, Hvidovre · NCT06888908 · Data updated 2026-11-12
This study is testing how blood volume changes in people having hip replacement surgery to see if it affects their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | Copenhagen University Hospital, Hvidovre Academic / other |
| Locations | 1 site (Copenhagen) |
| Status | Recruiting |
| Started | March 2025 |
| Main results expected | September 2026 |
| Study ends | September 2026 |
| Registry record updated | March 21, 2025 |
| Trial ID | NCT06888908 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older scheduled for elective total hip arthroplasty in a fast track setting who can participate in CO-rebreathing measurement.
✕Probably not a fit
Patients with significant intraoperative blood loss, those requiring blood transfusions, or individuals with coagulopathies or known orthostatic intolerance may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess changes in blood volume and fluid distribution in patients undergoing primary total hip arthroplasty. By utilizing carbon monoxide rebreathing, the study seeks to provide a non-invasive and accurate measurement of blood volume changes during the perioperative period. The research will also explore the relationship between these changes and the incidence of orthostatic insufficiency, which can impact patient recovery and outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved fluid management strategies during hip replacement surgeries, enhancing patient recovery and outcomes.
How similar studies have gone: While this approach using CO-rebreathing is innovative, similar studies have not been widely reported, indicating that this may be a novel investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients scheduled for an elective total hip arthoplasty (THA) in a standardized fast track setting. * Capable of participating in CO-rebreathing measurement * Age ≥ 18 years * Able to speak and understand Danish * Has provided written informed consent. Exclusion Criteria: * Intraoperative blood loss exceeding 750 mL. * Perioperative need for a blood transfusion. * Confirmed or suspected coagulopathies. * Factors that make CO-rebreathing measurement impossible. * Known orthostatic intolerance. * American Society of Anesthesiologists physical status (ASA) classification ≥ 4.
Where it's running
-
Hvidovre University Hospital
Copenhagen, Denmark Recruiting
Study contacts
- Study coordinator: Puk Kristiansen, MD
- Email: puk.kristiansen@regionh.dk
- Phone: +4530291189
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.