Investigating blood pressure drops after meals and surgery in older adults
Correlation Between Postprandial Hypotension and Perioperative Adverse Events Such as Post-induction Hypotension in the Elderly: a Prospective Observational Study.
This study looks at how drops in blood pressure after meals and during surgery might affect older adults aged 65 and up to help improve their care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Peking Union Medical College Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT05575661 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between postprandial hypotension (PPH) and post-induction hypotension (PIH) in elderly patients undergoing elective non-cardiac surgery. It focuses on patients aged 65 and older, assessing how these blood pressure drops may correlate with perioperative complications. The study will involve monitoring blood pressure changes in patients before and after meals and during the surgical induction phase to identify potential risks associated with these conditions. By understanding this correlation, the study seeks to improve patient outcomes in the elderly surgical population.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly patients aged 65 and older scheduled for elective non-cardiac surgery under general anesthesia.
Not a fit: Patients with significant vascular diseases, secondary hypertension, chronic kidney disease, or other specific conditions that affect blood pressure regulation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better management strategies for preventing hypotension-related complications in elderly surgical patients.
How similar studies have performed: While the specific correlation between PPH and PIH in elderly patients has not been extensively studied, related research on blood pressure management in surgical settings has shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Elderly patients (≥ 65 years old）; 2. Patients with American Society of Anesthesiologists(ASA) grade I-III; 3. Patients scheduled to undergo elective non-cardiac surgery under general anesthesia, with an anticipated surgical duration of over 1 hour； 4. Patients with intra-tracheal intubation following intravenous general ；anesthesia induction and maintenance； Exclusion Criteria: 1. Patients with vascular diseases such as aortic aneurysm, aortic dissection, symptomatic atherosclerotic obliterans, Buerger's disease, and Raynaud's syndrome 2. Patients with secondary hypertension, including renal hypertension and endocrine hypertension. 3. Patients with chronic kidney disease requiring dietary restrictions or dialysis. 4. Patients with Parkinson's disease or other conditions causing tremors. 5. Patients with problems related to oral food ingestion or those requiring enteral nutrition. 6. Patients with difficulties in measuring the upper extremities or communication problems that would interfere with study procedures. 7. Patients unable to remain in a supine position for at least 2 hours.
Where this trial is running
Beijing, Beijing Municipality
- Peking Union Medical College Hospital — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Li Xu, M.D. — Peking Union Medical College Hospital
- Study coordinator: Li Xu, M.D.
- Email: pumchxuli@163.com
- Phone: 8610-69156114
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.