Investigating blood microvesicles and exosomes in patients after bypass surgery
Study of Role of Blood Microvescicles and Exosomes in Patients With Graft Occlusion After Aortocoronary Bypass Surgery
This study looks at how tiny particles in the blood of patients who had heart bypass surgery might affect their recovery and the success of the surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 40 Years to 80 Years |
| Sex | All |
| Sponsor | Maria Cecilia Hospital Academic / other |
| Locations | 1 site (Cotignola, Ravenna) |
| Trial ID | NCT05411445 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients who have undergone coronary artery bypass graft (CABG) surgery to explore the role of circulating microvesicles (MVs) and exosomes in graft occlusion. It aims to understand how these small membrane vesicles, which are involved in cell communication and may serve as biomarkers for cardiovascular disease, correlate with surgical outcomes. The study will assess the quantity and pattern of MVs in the blood of participants to determine their potential impact on graft failure and overall patient prognosis.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 40 to 80 who have undergone CABG surgery and have an ejection fraction greater than 30%.
Not a fit: Patients requiring emergency interventions or those with significant changes in liver or kidney function may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved monitoring and management strategies for patients undergoing CABG surgery, potentially enhancing graft patency and long-term outcomes.
How similar studies have performed: While previous studies have explored the role of microvesicles in cardiovascular disease, this specific investigation into their association with CABG outcomes is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * between the ages of 40 and 80 * Ejection fraction\> 30% * coronary artery bypass surgery * informed consent * Willingness to carry out the follow-up visits and the assessments required by the protocol Exclusion Criteria: * emergency intervention * changes in liver or kidney function * changes in coagulation factors * associated interventions (valve replacement, carotid endarterectomy)
Where this trial is running
Cotignola, Ravenna
- Mch — Cotignola, Ravenna, Italy (Recruiting)
Study contacts
- Study coordinator: Alberto Albertini, MD
- Email: aalbertini@gvmnet.it
- Phone: +39 0545 217693
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.