Investigating blood flow patterns and stent thrombosis
Development of a Novel Method for Detailed Evaluation of Blood Flow Patterns in Stented Segments and Assessment of Their Role in Stent Thrombosis
This study is trying to see how blood flow patterns affect the risk of blood clots in patients who have had stents placed in their hearts.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Sex | All |
| Sponsor | Queen Mary University of London Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT06700018 on ClinicalTrials.gov |
What this trial studies
This observational study aims to examine how blood flow patterns influence thrombus formation in patients who have undergone OCT-guided percutaneous coronary interventions. Researchers will compare the blood flow patterns of patients who experienced stent thrombosis with those who did not, to identify hemodynamic markers that could predict such events. The study will utilize advanced imaging techniques and computational fluid dynamics to analyze shear stress and shear rate distributions in the stented vessels. A total of 120 patients will be involved, including 40 with stent thrombosis and 80 controls.
Who should consider this trial
Good fit: Ideal candidates are patients who have undergone OCT-guided percutaneous coronary interventions and have received a second-generation drug-eluting stent.
Not a fit: Patients who have not experienced stent thrombosis or have not undergone OCT-guided interventions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prediction and prevention of stent thrombosis, enhancing patient outcomes after coronary interventions.
How similar studies have performed: While some studies have explored hemodynamic factors in stent thrombosis, this approach using in vivo flow simulations is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergone OCT-guided percutaneous coronary intervention and implanted with a second-generation drug-eluting stent * Patients who have suffered thrombosis post-stent implantation Exclusion Criteria: \-
Where this trial is running
London
- Queen Mary University of London — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Christos Bourantas
- Email: c.bourantas@qmul.ac.uk
- Phone: +442073777000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.