Investigating blood flow patterns after artery recanalization in stroke patients
Correlation Between Changes in Arterial Wall Shear Stress and Prognosis Following Acute Major Intracranial Artery Occlusion and Recanalization
This study looks at how blood flow changes in stroke patients before and after a procedure to open blocked arteries, using special imaging to see if these changes can help us understand their recovery better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 160 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chonbuk National University Hospital Academic / other |
| Locations | 8 sites (Ansan, Gyeonggi-do and 7 other locations) |
| Trial ID | NCT06290271 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the blood flow characteristics in patients with acute occlusion of major intracranial arteries before and after recanalization. Utilizing time-of-flight magnetic resonance angiography (TOF-MRA), the study will explore the Signal Intensity Gradient (SIG) concept, which correlates with wall shear stress (WSS) and may reflect vascular health. By examining these parameters, the research seeks to enhance understanding of cerebral blood flow dynamics and their implications for patient outcomes following interventions like thrombectomy. The study will include patients who have undergone recanalization and have available imaging data.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with acute neurological impairments and confirmed occlusion of major cerebral arteries who have undergone recanalization.
Not a fit: Patients without available TOF-MRA imaging or those whose imaging quality is insufficient for analysis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the understanding of blood flow dynamics in stroke patients, potentially leading to better treatment strategies.
How similar studies have performed: While studies have explored aspects of wall shear stress in stroke patients, this specific approach using SIG in the context of recanalization is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals aged 18 years and above * Presenting with acute neurological impairments and demonstrating occlusion of major cerebral arteries (inclusive of one or more of the internal carotid artery, anterior cerebral artery, middle cerebral artery, posterior cerebral artery, vertebral artery, or basilar artery) as evidenced by brain MRA examinations * Arterial recanalization subsequent to interventions such as intravenous thrombolysis and/or endovascular thrombectomy. * Verification of the recanalized arteries on subsequent brain MRA imging * Availability of source images from intracranial TOF-MRA (stored in DICOM format) both before and after arterial recanalization Exclusion Criteria: * Absence of TOF-MRA imaging either before or after arterial recanalization * Brain MRI was performed, but TOF-MRA (DICOM source images) are missing * Image analysis is deemed challenging due to the quality of the Brain MR images * Intervention for vascular recanalization was unsuccessful, or re-occlusion was observed in the follow-up brain MRA
Where this trial is running
Ansan, Gyeonggi-do and 7 other locations
- Korea University Ansan Hospital — Ansan, Gyeonggi-do, Korea, Republic of (Not_yet_recruiting)
- Jeonbuk National University Hospital — Jeonju, Jeollabuk Do, Korea, Republic of (Not_yet_recruiting)
- Chungnam National University Hospital — Daejeon, Korea, Republic of (Recruiting)
- Chonnam National University Hospital — Gwangju, Korea, Republic of (Recruiting)
- Seoul National University Hospital — Seoul, Korea, Republic of (Not_yet_recruiting)
- Asan Medical Center — Seoul, Korea, Republic of (Recruiting)
- SMG-SNU Boramae Medical Center — Seoul, Korea, Republic of (Not_yet_recruiting)
- Ulsan University Hospital — Ulsan, Korea, Republic of (Recruiting)
Study contacts
- Principal investigator: Keun-Hwa Jung, Prof. — Seoul National University Hospital
- Study coordinator: Chan-Hyuk Lee, Prof.
- Email: bluewave0210@gmail.com
- Phone: +82-052-250-7089
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.