Investigating bleeding frequency in patients on ECMO with von Willebrand Factor issues
Study of the Frequency of Hemorrhages Associated With the Functional Anomalies of Willebrand Factor in Emergency Patients of a Veino Arterial or Veinous ECMO
This study looks at how often patients on ECMO for heart or lung problems bleed and how this relates to issues with a blood clotting factor.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 418 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Lille Academic / other |
| Locations | 7 sites (Arras and 6 other locations) |
| Trial ID | NCT03070912 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the frequency of hemorrhages in patients undergoing ECMO (extracorporeal membrane oxygenation) for cardiac or respiratory failure. It will assess how bleeding complications vary between different types of ECMO, specifically veno-arterial and veno-venous. Additionally, the study will investigate the relationship between these bleeding events and defects in von Willebrand Factor, which is crucial for blood clotting. The research is conducted at Lille University Hospital and its affiliated centers.
Who should consider this trial
Good fit: Ideal candidates include patients on ECMO for cardiac or respiratory failure who are referred to Lille University Hospital and have provided informed consent.
Not a fit: Patients who are pregnant, have preexisting bleeding disorders, or cannot provide consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better management of bleeding complications in patients receiving ECMO, improving overall patient outcomes.
How similar studies have performed: While there is limited data on this specific approach, studies on ECMO and bleeding complications have shown varying results, indicating a need for further investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * informed consent of patient or person in charge * patient supplied by an ECMO for cardiac or respiratory failure and referred to Lille University Hospital * patient affiliated to "french social security" Exclusion Criteria: * pregnant woman * no consent * no affiliation to * patient affiliated to ' * preexisting bleeding disorders
Where this trial is running
Arras and 6 other locations
- Ch Arras — Arras, France (Recruiting)
- CH Boulogne — Boulogne-sur-Mer, France (Recruiting)
- Ch Douai — Douai, France (Recruiting)
- CH Dunkerque — Dunkerque, France (Recruiting)
- Hôpital Cardiologie, CHU — Lille, France (Recruiting)
- Ch Tourcoing — Tourcoing, France (Recruiting)
- Ch Valenciennes — Valenciennes, France (Recruiting)
Study contacts
- Principal investigator: Antoine RAUCH, MD,PhD — University Hospital, Lille
- Study coordinator: Antoine RAUCH, MD,PhD
- Email: antoine.rauch@chru-lille.fr
- Phone: 320445962 (poste 29673)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.