Investigating B and CD4 T Cell Roles in Multiple Sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify the pathogenic properties of B and CD4 T cell subsets in patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS). By analyzing blood and cerebro-spinal fluid samples from 150 participants, the researchers will explore the immune mechanisms involved in different forms of MS. The goal is to enhance understanding of disease progression and potentially develop new therapeutic strategies. The study is conducted at Bordeaux University Hospital, focusing on the immune response in MS patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* male or female subjects ;
* Age ≥ 18 years;
* subjects with MS defined by 2010 revised McDonald criteria or presenting a clinical isolated syndrome;
* patients for which a blood draw and / or lumbar puncture to collect CSF is performed for diagnostic or therapeutic purpose;
* affiliated to an health insurance system;
* and who agree to participate in the study.

Exclusion Criteria:

* Pregnant or breastfeeding women,
* patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent)

Where it's running

• CHU de Bordeaux - service de neurologie
  Bordeaux, France Recruiting

Study contacts

• Principal investigator: Aurélie RUET, Prof — University Hospital, Bordeaux
• Study coordinator: Aurélie RUET, Prof
• Email: aurelie.ruet@chu-bordeaux.fr
• Phone: 05 56 79 55 21

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.