Investigating ATP production in patients with chronic cough

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with refractory and unexplained chronic cough (RCC/UCC) to explore the role of ATP production by the airway epithelium. It aims to compare ATP levels and gene expression related to ATP production between RCC/UCC patients and healthy controls. The study will utilize bronchoscopy to assess ATP production and its potential as a biomarker for targeted treatment. Additionally, it seeks to determine if mechanical and chemical stimulation affects ATP release in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria for RCC/UCC:

* Patients with a history of RCC/UCC.
* Normal Chest X-ray in the last 5 years.
* No Evidence of Airflow Obstruction (FEV1/FVC ratio above LLN)
* Cough Severity VAS ≥ 40 mm at screening.

Inclusion Criteria for Healthy Controls:

* No history of chronic cough, asthma, COPD, or clinical history of bronchiectasis or interstitial lung disease
* No current smokers or those with \>10 pack year history.
* No evidence of airflow obstruction ( FEV1/FVC ratio above LLN).
* Able to understand and give written informed consent.

Exclusion Criteria:

* Participants who are currently established on treatment and their chronic cough is well controlled.
* Unable to perform acceptable and reproducible spirometry.
* Participants with a positive covid-19 test within 2 weeks of screening.
* Current smoker or ex-smoker with ≥20 pack year smoking history and abstinence of ≤6 months
* Symptoms of upper respiratory tract infection in the last 1 month which have not resolved
* Lower respiratory tract infection or pneumonia in the last 1 month
* Asthma exacerbation in the previous month requiring an increase or start of an inhaled corticosteroid (ICS) or oral corticosteroid (OCS)
* Significant other primary pulmonary disorders in particular; pulmonary embolism, pulmonary hypertension, lung cancer, cystic fibrosis, significant radiologically proven emphysema, interstitial lung disease or bronchiectasis.
* History of psychiatric illness, drug or alcohol abuse which may interfere in the participation of the trial.
* Allergy or intolerance to sedation medication including fentanyl and midazolam, or a history of complications during procedural sedation
* Severe coagulopathy, bleeding disorder, or medical need for anti- coagulation that would increase the risk of endobronchial biopsy as determined by the investigator

Where it's running

• Imran Satia
  Hamilton, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Imran Satia, MB BChir (cantab) MRCP PhD — McMaster University
• Study coordinator: Imran Satia, MB BChir (cantab) MRCP PhD
• Email: satiai@mcmaster.ca
• Phone: 905-521-2100

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Inhaled ATP cough challenge: safety and repeatability

  We will test whether inhaling ATP safely and consistently triggers cough in healthy adults and in people with mild asthma or chronic cough.

  Recruiting Phase 1 McMaster University · Hamilton, Ontario · NCT07085975

• Behavioral Cough Suppression Therapy with or without an inhaled aid for refractory chronic cough

  This study tests whether adding an inhaled substance to behavioral cough suppression helps people with persistent chronic cough see if it works better than behavior therapy alone.

  Recruiting at 2 sites Phase 2 University of Montana · Aurora, Colorado and 2 other locations · NCT06960759

• Understanding airway mucus blockages in asthma, COPD, and chronic cough across Canada

  This project will use chest CT scans and clinical data to see if mucus plugs in the airways are linked to symptoms in adults with moderate-to-severe asthma, COPD, or chronic cough.

  Recruiting McMaster University · Vancouver, British Columbia and 6 other locations · NCT06858748

• Injecting steroids to treat chronic cough

  This study is testing if steroid injections can help people with a long-lasting cough that doesn't have a clear cause feel better compared to a placebo.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT06634823

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.