Investigating a new therapy for early relapse in AML patients

ALLG AMLM26 INTERCEPT (Investigating Novel Therapy to Target Early Relapse and Clonal Evolution as Pre-emptive Therapy in AML): A Multi-arm, Precision-based, Recursive, Platform Trial

This study is testing a new therapy for people with acute myeloid leukemia (AML) to see if it can help prevent early relapse and improve their response to treatment.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 12 (estimated)
• Ages: 18 Years to 55 Years
• Sex: All
• Sponsor: M.D. Anderson Cancer Center (Academic / other)
• Drugs / interventions: prednisone
• Locations: 1 site (Houston, Texas)
• Trial ID: NCT06664879 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate the efficacy of a targeted and tailored sequential therapy for patients with acute myeloid leukemia (AML). It focuses on measuring minimal residual disease (MRD) response to decision-rule guided therapy and assessing the durability of this response. The study also investigates the safety and tolerability of the therapies used, including MBG-453 and Azacitidine, and explores the dynamics of MRD response in patients who have experienced treatment failure. Additionally, it seeks to understand the mechanisms of resistance and the overall efficacy of the treatment platform in managing AML.

Who should consider this trial

Good fit: Ideal candidates for this study are AML patients who meet specific mutation criteria and MRD eligibility, and have an ECOG performance status of 0-2.

Not a fit: Patients who are not eligible due to severe comorbidities, active acute graft-versus-host disease, or inadequate renal function may not benefit from this study.

Why it matters

Potential benefit: If successful, this therapy could significantly improve outcomes for AML patients by providing a more effective treatment strategy for those at risk of early relapse.

How similar studies have performed: Other studies have shown promise with similar targeted therapies in AML, indicating potential for success in this novel approach.

Eligibility criteria

Inclusion Criteria:

1. Meets inclusion criteria outlined in the AMLM26 INTERCEPT Master Protocol including:

   1. Master Protocol Inclusion Criteria listed in Master Protocol Appendix 3.0.
   2. the mutation/mutations specified for this treatment arm in Master Protocol Appendix 2.0 Compendium of Actionable Domains and Allocation Rules
2. Meets MRD eligibility for INTERCEPT therapy based on a screening sample taken no more than 42 days prior to cycle 1 of day 1 of treatment on this treatment arm. Refer to Master Protocol Appendix 5 for the definitions of MRD progression/failure. Eligibility will be confirmed by the MRD review committee.
3. ECOG 0-2
4. Patients entering this arm post-allogeneic stem cell transplantation will need to have an absolute lymphocyte count of .0.2 x 109/L and no evidence of active acute graft-versushost disease (GVHD)
5. Subject must have adequate renal function as demonstrated by a creatinine clearance .

30 mL/min; calculated by the Cockcroft Gault formula or measured by 24-hours urine collection 6. Subject must have adequate liver function as demonstrated by:

1. aspartate aminotransferase (AST) . 3.0 \~ ULN
2. alanine aminotransferase (ALT) . 3.0 \~ ULN
3. bilirubin . 1.5 \~ ULN (unless bilirubin rise is due to Gilbert fs syndrome or of nonhepatic origin) 7. Agrees to follow the recommended contraception procedures for this treatment domain

Exclusion Criteria:

Presence of any general exclusion criteria outlined in the AMLM26 INTERCEPT Master Protocol 2. Prior allogeneic stem cell transplantation within 3 months of post-conditioning or on

* 10mg/day prednisolone for graft vs host disease 3. Subject is HIV positive 4. Patients with .5% myeloblasts in bone marrow on morphologic assessment 5. Evidence of other clinically significant uncontrolled condition(s) including, but not limited to:

  1. Uncontrolled and/or active systemic infection (viral, bacterial or fungal)
  2. Acute/Chronic hepatitis B virus (HBV) or hepatitis C (HCV) requiring treatment. Note: subjects with serologic evidence of prior vaccination to HBV (i.e. hepatitis B surface (HBs) antigen negative-, anti-HBs antibody positive and anti-hepatitis B core (HBc) antibody negative) or positive anti-HBc antibody from intravenous immunoglobulins (IVIG) or resolved HBV infection may participate. 6. Systemic chronic corticosteroid therapy (≥10 mg/day prednisone or equivalent) or any immunosuppressive therapy within 7 days of first dose of study treatment. Topical, inhaled, nasal and ophthalmic steroids are allowed. 7. For initial enrolment to INTERCEPT therapy, patients who have received previous TIM3 inhibitor treatment are excluded. This exclusion criteria does not apply to patients crossing-over from MBG453 arm to the combination MBG453 + azacitidine arm, unless MBG453 was ceased due to MBG453-related toxicity. 8. Patients with active, known or suspected autoimmune disease. Patients with vitiligo, type I diabetes, residual hypothyroidism only requiring hormone replacement, psoriasis not requiring systemic treatment or conditions not expected to recur should not be excluded 9. History of or current drug-induced interstitial lung disease or pneumonitis grade .2 10. Subject has been diagnosed with another malignancy, unless disease-free for at least 2 years and not needing active treatment. Patients with fully excised BCC/SCC/CIN or other minor malignancy are not excluded 11. Subject has clinically significant abnormality of coagulation profile, such as disseminated intravascular coagulation 12. Use of any live vaccines against infectious diseases (i.e. Influenza, varicella, pneumococcus) within 4 weeks of initiation of study treatment 13. Impaired cardiac function or clinically significant cardiac disease, including any of the following:
* Clinically significant and/or uncontrolled heart disease such as congestive heart failure requiring treatment (NYHA Grade . 2) with an LVEF of \<40%, uncontrolled hypertension or clinically significant arrhythmia
* Acute myocardial infarction or unstable angina pectoris . 3 months prior to study entry 14. Known hypersensitivity to azacitidine or mannitol.

Where this trial is running

Houston, Texas

• The University of Texas MD Anderson Cancer Center — Houston, Texas, United States (Recruiting)

Study contacts

• Principal investigator: Courtney DiNardo, MD — The University of Texas MD Anderson Cancer Center
• Study coordinator: Courtney DiNardo, MD

Conditions AML