Intravenous labetalol versus lignocaine to reduce heart rate and blood pressure spikes during intubation for laparoscopic gallbladder removal
Official title: Comparative Efficacy of Intravenous Labetalol and Lignocaine in Mitigating Hemodynamic Responses to Laryngoscopy During Laparoscopic Cholecystectomy: A Randomized Controlled Trial
Run by Lady Reading Hospital, Pakistan · NCT07192081 · Data updated 2026-11-12
This test will try a single IV dose of labetalol or lignocaine given before intubation to see which better prevents sudden heart rate and blood pressure rises in adults having elective laparoscopic gallbladder surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 116 (estimated) |
| Sponsor | Lady Reading Hospital, Pakistan Government |
| Locations | 1 site (Peshawar, Khyber Pakhtunkhwa) |
| Status | Recruiting |
| Started | June 5, 2025 |
| Main results expected | January 4, 2026 |
| Study ends | February 28, 2026 |
| Registry record updated | September 25, 2025 |
| Trial ID | NCT07192081 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 to 60 with ASA physical status I or II scheduled for elective laparoscopic cholecystectomy who are not on antihypertensive medications and can give informed consent.
✕Probably not a fit
People with significant cardiovascular, renal, hepatic, or endocrine disease, those on antihypertensives, pregnant or lactating patients, those with BMI ≥35, or those with an anticipated difficult airway are excluded and may not benefit from the study's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial at Hayatabad Medical Complex in Peshawar will randomly assign 116 adults undergoing elective laparoscopic cholecystectomy to receive either IV labetalol (0.25 mg/kg) or IV lignocaine (1.5 mg/kg) three minutes before laryngoscopy. The primary outcome is maintaining heart rate and mean arterial pressure within ±20% of baseline during and after intubation, with secondary recordings of perioperative blood pressure trends, intubation details, rescue medications, and adverse events. Eligible participants are ASA I–II adults aged 18–60 who provide consent, with exclusions for current antihypertensive therapy, significant cardiovascular or systemic disease, pregnancy, high BMI, or predicted difficult airway. The trial directly compares two commonly used peri-intubation drugs to inform safer anesthetic choices.
Why it matters
Potential benefit: If successful, the results could help anesthesiologists choose the safer and more effective drug to keep heart rate and blood pressure stable during intubation and reduce perioperative cardiovascular risk.
How similar studies have gone: Both labetalol and IV lignocaine have been shown in prior studies to blunt intubation-related sympathetic surges, but direct head-to-head evidence specifically in laparoscopic cholecystectomy is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA Grade I and II * Age 18 to 60 years * Elective laparoscopic cholecystectomy * Both genders * Informed consent given Exclusion Criteria: * Hypersensitivity to labetalol/lignocaine * Hypertensive on antihypertensives * ASA Grade III or more * Cardiovascular, renal, hepatic, or endocrine issues * Pregnant/lactating * BMI ≥ 35 * Anticipated difficult airway
Where it's running
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Hayatabad Med Complex
Peshawar, Khyber Pakhtunkhwa, Pakistan Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.