Intranasal lidocaine spray to block nasal nerves during partial turbinectomy
Efficacy of Intranasal Sphenopalatine Ganglion Block by Lidocaine Spray for Partial Turbinectomy Surgeries
This study tests whether applying an intranasal lidocaine spray before partial turbinectomy can numb the sphenopalatine ganglion to reduce pain and perioperative opioid use for adults having the surgery.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT07299630 on ClinicalTrials.gov |
What this trial studies
This phase 3 interventional trial applies topical intranasal lidocaine targeting the sphenopalatine ganglion in adults undergoing elective partial turbinectomy, alongside balanced anesthesia. The approach is noninvasive and uses a lidocaine spray (versus the standard perioperative care) to try to improve the surgical field and reduce postoperative pain and opioid requirements. Eligible participants are adults 18 or older without significant liver or kidney impairment and with expected operative time under 90 minutes. Outcomes focus on perioperative opioid consumption, pain control, and recovery measures after day-case turbinectomy performed at a single center.
Who should consider this trial
Good fit: Adults aged 18 or older scheduled for elective partial turbinectomy with expected operative time under 90 minutes and without major liver or kidney disease are the intended candidates.
Not a fit: Patients with kidney or liver impairment, pregnancy or breastfeeding, allergy to study drugs, or surgeries expected to last more than 90 minutes are unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, the spray could lower opioid use and improve pain control and recovery after partial turbinectomy.
How similar studies have performed: Previous studies of SPG blocks and topical lidocaine in nasal surgery and headache management have shown promising results, but noninvasive SPG blockade specifically by intranasal spray is less well established for postoperative pain.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing elective partial turbinectomy surgery * Age 18 years or older Exclusion Criteria: * Patient refusal * Kidney or liver impairment * Pregnant or breast-feeding women * Allergy to any of the drugs used in the study * OR time more than 90 minutes (defined as time from anaesthesia induction to end of surgery, excluding extubation time)
Where this trial is running
Cairo
- Ain shams university hospitals — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Abdallah soudi, M.D.
- Email: dr.soudi2014@med.asu.edu.eg
- Phone: 02- 01111228925
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.